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Identifying Amphetamine Addiction Risk Variants by Whole Genome Sequencing

Description: PUBLIC HEALTH RELEVANCE: Addiction and drug abuse is a common and costly public health problem and understanding the genetic basis of addiction and drug abuse has enormous public health relevance. We plan to investigate for the full genome sequences of individuals suffering from amphetamine addiction to gain a better understanding of the genetic basis of addiction and drug abuse.
Funding type: research
Funder scheme: R01
Start date: 2013-03-15
End date: 2020-01-31
Investigator: THORGEIR E. THORGEIRSSON
Institution: DECODE GENETICS, EHF
Subfield: Genetics
Funded outputs count: 10
Funder award ID: R01DA034076
OpenAlex ID: G6135000629
A large-scale genome-wide association study meta-analysis of cannabis use disorder
2020 · Emma C Johnson, Ditte Demontis, et al. · The Lancet Psychiatry · 343
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The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls
2019 · Jonathan R.I. Coleman, Héléna A. Gaspar, et al. · Biological Psychiatry · 199
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Genome-wide association study implicates CHRNA2 in cannabis use disorder
2019 · Ditte Demontis, Veera Manikandan Rajagopal, et al. · Nature Neuroscience · 131
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
2019 · Mengzhen Liu, HUNT All-In Psychiatry, et al. · Nature Genetics · 1,890
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
2018 · eQTLGen, Naomi R. Wray, et al. · Nature Genetics · 2,997
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Truncating mutations in RBM12 are associated with psychosis
2017 · Stacy Steinberg, Steinunn Gudmundsdottir, et al. · Nature Genetics · 70
Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly
2017 · Florian Zink, Simon N. Stacey, et al. · Blood · 777
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Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction
2017 · Gunnar W. Reginsson, Andres Ingason, et al. · Addiction Biology · 112
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Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders
2016 · Min-Tzu Lo, David A Hinds, et al. · Nature Genetics · 444
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Psychometric properties of the Icelandic NEO-FFI in a general population sample compared to a sample recruited for a study on the genetics of addiction
2013 · Gyda Bjornsdottir, Fridrik H. Jonsson, et al. · Personality and Individual Differences · 23
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