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Amplifying muscle and metabolic recovery in aging using metformin and leucine

Description: Narrative We propose to use metformin and leucine to optimize muscle and metabolic recovery in aging with an established mouse model of disuse and recovery. Our long-range goal is to develop a novel, yet safe, pharmacological approach by repurposing metformin (and in combination with leucine) to preserve muscle health in older adults who have slow and impaired muscle and metabolic recovery as a result of hospitalization, injury, surgery, or illness.!

Funder: National Institute on Aging

Funding type: research

Funder scheme: R03

Start date: 2019-09-01

End date: 2022-05-31

Investigator: MICAH J DRUMMOND

Institution: UNIVERSITY OF UTAH

Funded outputs count: 3

Funder award ID: R03AG064216

OpenAlex ID: G7126254446

Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail

2023 · Jonathan J. Petrocelli, Naomi M.M.P. de Hart, et al. · Aging · 8

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Metformin and leucine increase satellite cells and collagen remodeling during disuse and recovery in aged muscle

2021 · Jonathan J. Petrocelli, Ziad S. Mahmassani, et al. · The FASEB Journal · 37

PGC-1α-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging

2020 · Jonathan J. Petrocelli, Micah J. Drummond · International Journal of Environmental Research and Public Health · 39

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