Intrarenal Arteries Sense N-formyl Peptides Leading to Vascular Injury in Sepsis
Description: PUBLIC HEALTH RELEVANCE (provided by applicant): Systemic inflammatory response syndrome (SIRS) is one of the principal causes of death in intensive care units in the USA. Acute kidney injury (AKI) is a common symptom of SIRS. This research presents the intriguing hypothesis that fragments from damaged mitochondria, released into the circulation after trauma, are recognized by the vessels of the kidney as an infection. Understanding this will help develop new treatments aimed at inhibiting the devastating interaction between mitochondrial fragments and the renal vascular system.
Funding type: research
Funder scheme: R00
Start date: 2016-09-01
End date: 2022-11-30
Investigator: CAMILLA FERREIRA WENCESLAU (lead)
Institutions: University of South Carolina, UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
Topic: Acute Kidney Injury Research
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 41
Funder award ID: R00GM118885
OpenAlex ID: G7765228531