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Exosome-based therapeutics for heart failure

Description: PROJECT NARRATIVE Cardiosphere-derived cells (CDCs), which are effective in various models of heart failure, work via the secretion of exosomes. Here we propose to develop trenchant methods to assess exosome biodistribution, to enhance exosome targeting and potency, and to immortalize CDCs as a stable source of therapeutic exosomes. The studies will advance our mechanistic understanding of exosome biology, while constituting an important translational step towards the development of exosomes as off-the-shelf cell-free agents to treat heart failure.
Funding type: research
Funder scheme: R01
Start date: 2014-07-11
End date: 2023-01-31
Investigator: EDUARDO MARBAN (lead)
Funded outputs count: 47
Funder award ID: R01HL124074
OpenAlex ID: G8059494500
Small noncoding RNA TY2 enhances efferocytosis and improves outcomes in a mouse model of sepsis
2026 · Alessandra Ciullo, Xaviar M. Jones, et al. · JCI Insight
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Intravenous and oral administration of the synthetic RNA drug, TY1, reverses heart failure with preserved ejection fraction in mice
2024 · Kazutaka Miyamoto, Xaviar M. Jones, et al. · Basic Research in Cardiology · 6
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Non-coding RNA yREX3 from human extracellular vesicles exerts macrophage-mediated cardioprotection via a novel gene-methylating mechanism
2024 · Alessandra Ciullo, Liang Li, et al. · European Heart Journal · 22
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Rejuvenating effects of young extracellular vesicles in aged rats and in cellular models of human senescence
2023 · Lilian Grigorian Shamagian, Russell G. Rogers, et al. · Scientific Reports · 34
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Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases
2023 · Guoping Li, Tianji Chen, et al. · Journal of Extracellular Vesicles · 126
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Cell therapy attenuates endothelial dysfunction in hypertensive rats with heart failure and preserved ejection fraction
2022 · Geoffrey de Couto, Thassio Mesquita, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 18
On the cellular origin of cardiosphere-derived cells (CDCs)
2022 · Eduardo Marbán, Ke Liao · Basic Research in Cardiology · 16
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Biodistribution of unmodified cardiosphere‐derived cell extracellular vesicles using single RNA tracing
2022 · Alessandra Ciullo, Chang Li, et al. · Journal of Extracellular Vesicles · 31
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Extracellular Vesicles Secreted by TDO2-Augmented Fibroblasts Regulate Pro-inflammatory Response in Macrophages
2021 · Kiel A. Peck, Alessandra Ciullo, et al. · Frontiers in Cell and Developmental Biology · 10
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Myofilament Phosphorylation in Stem Cell Treated Diastolic Heart Failure
2021 · Daniel Soetkamp, Romain Gallet, et al. · Circulation Research · 37
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Extracellular vesicles from immortalized cardiosphere-derived cells attenuate arrhythmogenic cardiomyopathy in desmoglein-2 mutant mice
2021 · Yen-Nien Lin, Thassio Mesquita, et al. · European Heart Journal · 84
Regulatory T cell activation, proliferation, and reprogramming induced by extracellular vesicles
2021 · Akbarshakh Akhmerov, Russell Rogers, et al. · The Journal of Heart and Lung Transplantation · 20
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Pathogenesis of arrhythmogenic cardiomyopathy: role of inflammation
2021 · Yen-Nien Lin, Ahmed Ibrahim, et al. · Basic Research in Cardiology · 32
Mechanistic and therapeutic distinctions between cardiosphere-derived cell and mesenchymal stem cell extracellular vesicle non-coding RNA
2021 · Ann-Sophie Walravens, Sasha Smolgovsky, et al. · Scientific Reports · 25
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Exosomally derived Y RNA fragment alleviates hypertrophic cardiomyopathy in transgenic mice
2021 · Feng Huang, Na Na, et al. · Molecular Therapy — Nucleic Acids · 27
Casein‐enhanced uptake and disease‐modifying bioactivity of ingested extracellular vesicles
2021 · Mark A. Aminzadeh, Mario Fournier, et al. · Journal of Extracellular Vesicles · 14
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Small molecule inhibitors and culture conditions enhance therapeutic cell and EV potency via activation of beta-catenin and suppression of THY1
2020 · Ahmed Gamal-Eldin Ibrahim, Chang Li, et al. · Nanomedicine Nanotechnology Biology and Medicine · 4
Extracellular Vesicles as Therapeutic Agents for Cardiac Fibrosis
2020 · Russell G. Rogers, Alessandra Ciullo, et al. · Frontiers in Physiology · 41
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Mechanisms of atrial fibrillation in aged rats with heart failure with preserved ejection fraction
2020 · Thassio Ricardo Ribeiro Mesquita, Rui Zhang, et al. · Heart Rhythm · 65
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Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories
2019 · Ahmed G. E. Ibrahim, Chang Li, et al. · Nature Biomedical Engineering · 70
Disease-modifying bioactivity of intravenous cardiosphere-derived cells and exosomes in mdx mice
2019 · Russell G. Rogers, Mario Fournier, et al. · JCI Insight · 30
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Disease-modifying bioactivity of intravenous cardiosphere-derived cells and exosomes in mdx mice
2019 · Russell G. Rogers, Mario Fournier, et al. · JCI Insight · 85
Letter by Ibrahim et al Regarding Article, “Lack of Cardiac Improvement After Cardiosphere-Derived Cell Transplantation in Aging Mouse Hearts”
2018 · Ahmed Ibrahim, Lilian Grigorian-Shamagian, et al. · Circulation Research · 3
Targeting extracellular vesicles to injured tissue using membrane cloaking and surface display
2018 · Travis J. Antes, Ryan C. Middleton, et al. · Journal of Nanobiotechnology · 261
Ventricular Arrhythmias Underlie Sudden Death in Rats With Heart Failure and Preserved Ejection Fraction
2018 · Jae Hyung Cho, Rui Zhang, et al. · Circulation Arrhythmia and Electrophysiology · 49
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