The mechanism of high fat diet induced neural inflammation and obese
Description: In mice, ghrelin’s orexigenic activity was abolished after 2-4 weeks HFD, consistent with the timing of accumulation and activation of macrophages and microglia in the nodose ganglion and hypothalamus. Calorie-restricted weight loss restored ghrelin responsiveness and alleviated the upregulation of macrophage/microglia activation markers and inflammatory cytokines.Aged mice easily gained weight during short-term HFD feeding, and required many days to adapt their energy intake. One-day HFD in aged mice induced inflammation in the distal colon, but not in the nodose ganglion or hypothalamus. The anorexic effect of GLP-1 was attenuated in aged mice. mRNA expression of the gene encoding the GLP-1 receptor in the nodose ganglion was significantly lower in aged mice than in young mice. These findings suggest that adaptation of energy intake regulation was attenuated in aged mice, causing them to become obese in response to short-term HFD feeding.
Amount: ¥4,680,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2016-04-01
End date: 2019-03-31
Investigator: Hideyuki Sakoda
Institution: University of Miyazaki
Funded outputs count: 7
Funder award ID: 16K09761
OpenAlex ID: G2186534069