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Mosaic loss of Y chromosome in blood and heart failure

Description: NARRATIVE Loss of the Y chromosome in the blood of males increases with age, and it is associated with diminished survival and an increase risk of various diseases. However, it is not known if the loss of the Y chromosome has a causal role in age-associated diseases or whether it is an epiphenomenon of biological aging processes. We will employ novel mouse models to test whether the loss of the Y chromosome in blood cells impacts pathological cardiac remodeling.
Funding type: research
Funder scheme: R01
Start date: 2021-09-15
End date: 2026-05-31
Investigator: KENNETH WALSH
Institution: UNIVERSITY OF VIRGINIA
Funded outputs count: 29
Funder award ID: R01AG073249
OpenAlex ID: G9000884509
Space radiation promotes clonal hematopoiesis and hematologic disease upon aging in a driver gene and sex-specific manner
2026 · Megan A. Evans, Heather Doviak, et al. · iScience
The Immunological Consequences of Clonal Hematopoiesis in Heart Failure
2026 · Megan A. Evans, Kenneth Walsh · Immunological Reviews · 4
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Hematopoietic loss of Y chromosome activates immune checkpoints and contributes to impaired senescent cell clearance and renal disease
2025 · Yohei Arai, Nicholas W. Chavkin, et al. · Science Translational Medicine · 16
Clonal Hematopoiesis in Cancer and Cardiovascular Disease
2025 · Megan A. Evans, Kenneth Walsh · JACC CardioOncology · 12
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Mosaic loss of chromosome Y in blood is associated with male susceptibility for idiopathic pulmonary fibrosis
2025 · Josefin Bjurling, Nicholas W. Chavkin, et al. · Communications Medicine · 13
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Contributions of Noncardiac Organ–Heart Immune Crosstalk and Somatic Mosaicism to Heart Failure: Current Knowledge and Perspectives
2025 · Marinos Kallikourdis, Jesse D. Cochran, et al. · Circulation Research · 11
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Clonal Hematopoiesis Increases Hypertension and Sympathetic Activity and Is Reversed by Renal Denervation
2025 · Ariel H. Polizio, Lucila Marino, et al. · Hypertension · 4
Tet2-mediated clonal hematopoiesis modestly improves neurological deficits and is associated with inflammation resolution in the subacute phase of experimental stroke
2024 · Megan A. Evans, Nicholas W. Chavkin, et al. · Frontiers in Cellular Neuroscience · 4
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The emerging role of clonal haematopoiesis in the pathogenesis of dilated cardiomyopathy
2024 · Job A J Verdonschot, Jose J Fuster, et al. · European Heart Journal · 9
The emergence of clonal hematopoiesis as a disease determinant
2024 · Kenneth Walsh · Journal of Clinical Investigation · 11
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Experimental TET2 Clonal Hematopoiesis Predisposes to Renal Hypertension Through an Inflammasome-Mediated Mechanism
2024 · Ariel H. Polizio, Lucila Marino, et al. · Circulation Research · 32
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Can dental problems be indicative of clonal hematopoiesis?
2024 · Soichi Sano, Kenneth Walsh · Cell Research
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Mosaic Loss of the Y Chromosome Is Enriched in Patients With Wild-Type Transthyretin Cardiac Amyloidosis and Associated With Increased Mortality
2024 · Mark C. Thel, Jesse D. Cochran, et al. · Circulation Heart Failure · 8
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Clonal Hematopoiesis: The Emergent CVD Risk Factor
2024 · Jesse D. Cochran, Kenneth Walsh · Arteriosclerosis Thrombosis and Vascular Biology · 4
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Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure
2024 · Keita Horitani, Nicholas W. Chavkin, et al. · Nature Cardiovascular Research · 45
Clonal Hematopoiesis
2024 · Kenneth Walsh, Jesse D. Cochran, et al. · JACC Heart Failure
Regulators of clonal hematopoiesis and physiological consequences of this condition
2023 · Eunbee Park, Megan A. Evans, et al. · The Journal of Cardiovascular Aging · 4
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Clonal Hematopoiesis and Transcatheter Aortic Valve Replacement
2023 · Megan A. Evans, Kenneth Walsh · JACC Basic to Translational Science · 2
Obesity accelerates endothelial-to-mesenchymal transition in adipose tissues of mice and humans
2023 · Nicholas W. Chavkin, Tanvi Vippa, et al. · Frontiers in Cardiovascular Medicine · 14
Clonal Hematopoiesis in Clinical and Experimental Heart Failure With Preserved Ejection Fraction
2023 · Jesse D. Cochran, Yoshimitsu Yura, et al. · Circulation · 73
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Mosaic Loss of Y Chromosome in White Blood Cells: Its Impact on Men’s Health
2023 · Soichi Sano, Mark C. Thel, et al. · Physiology · 10
Clonal Hematopoiesis: From Macrovascular to Microvascular Disease
2023 · Jesse Cochran, Kenneth Walsh · Arteriosclerosis Thrombosis and Vascular Biology · 2
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Clonal hematopoiesis: the nonhereditary genetics of age-associated cardiovascular disease
2023 · Soichi Sano, Mark C. Thel, et al. · Current Opinion in Cardiology · 2
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Clonal Hematopoiesis: Connecting Aging and Inflammation in Atherosclerosis
2023 · Ariel H. Polizio, Eunbee Park, et al. · Current Atherosclerosis Reports · 20
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Development of a Mouse Model of Hematopoietic Loss of Y Chromosome
2023 · Soichi Sano, Kenneth Walsh · BIO-PROTOCOL · 5
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