Award

Regulation of Mitochondrial Dna-mediated Signaling and Its Contribution to Cellular and Organismal Aging

Description: Project Narrative: It is necessary to discover and fully elucidate the molecular mechanisms that underlie the aging process in order to develop novel therapeutic strategies to delay the onset of age-related diseases and extend healthy lifespan. The project aims to understand the regulation of mtDNA-mediated signaling, which engages pathways known to promote aging, and elucidate the contribution of mtDNA to cellular and organismal aging.
Funding type: fellowship
Funder scheme: F31
Start date: 2018-12-01
End date: 2022-11-30
Investigator: ALVA GABRIELA SAINZ
Institution: YALE UNIVERSITY
Funded outputs count: 7
Funder award ID: F31AG062099
OpenAlex ID: G4075489559
2024 · Alva G. Sainz, Gladys R. Rojas, et al. · The Journal of Cell Biology · 6
2023 · Stella Victorelli, Hanna Salmonowicz, et al. · Nature · 690
2023 · Kailash Chandra Mangalhara, Siva Karthik Varanasi, et al. · Science · 128
2022 · Mark L. Hepokoski, Mazen Odish, et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 24
2021 · Zheng Wu, Alva G. Sainz, et al. · Trends in Biochemical Sciences · 84
2019 · Zheng Wu, Sebastian Oeck, et al. · Nature Metabolism · 145
Year
Topic