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757729

Funded outputs count: 17
Funder award ID: 757729
OpenAlex ID: G2199907231
GRASP55 maintains lysosome function by controlling sorting of lysosomal enzymes at the Golgi
2026 · Julian Nüchel, Maryam Omidi, et al. · EMBO Reports · 4
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ATM-dependent RHEB phosphorylation couples DNA damage to lysosomal mTORC1 signaling to orchestrate the cellular response to genotoxic stress
2026 · Jiyoung Pan, Aurelio A. Teleman, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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TSC1 phosphorylation by lysosomal mTORC1 establishes a minimal autoregulatory feedback loop
2026 · Andreas Lamprakis, Constantinos Demetriades · bioRxiv (Cold Spring Harbor Laboratory)
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The tumor suppressor CYLD acts as a deubiquitinase for mTOR to constrain its activity
2025 · Stephanie A. Fernandes, Jiyoung Pan, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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Spatially and Functionally Distinct mTORC1 Entities Orchestrate the Cellular Response to Amino Acid Availability
2023 · Stephanie A. Fernandes, Danai-Dimitra Angelidaki, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2
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Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor
2023 · Raffaele Nicastro, Laura Brohée, et al. · Nature Cell Biology · 43
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Unbiased evaluation of rapamycin's specificity as an mTOR inhibitor
2023 · Filippo Artoni, Nina Grützmacher, et al. · Aging Cell · 27
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Comprehensive Evaluation of Rapamycin’s Specificity as an mTOR Inhibitor
2022 · Filippo Artoni, Nina Grützmacher, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Malonyl-CoA is an ancient physiological ATP-competitive mTORC1 inhibitor
2022 · Raffaele Nicastro, Laura Brohée, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity
2022 · Wenming Huang, Chun Kew, et al. · Nature Aging · 34
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A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids
2022 · Peter Gollwitzer, Nina Grützmacher, et al. · Nature Cell Biology · 76
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Decreased spliceosome fidelity inhibits mTOR signalling and promotes longevity via an intron retention event
2022 · Wenming Huang, Chun Kew, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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GRASPing the unconventional secretory machinery to bridge cellular stress signaling to the extracellular proteome
2021 · Constantinos Demetriades, Julian Nüchel, et al. · Cell Stress · 4
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The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging
2021 · Stephanie A. Fernandes, Constantinos Demetriades · Frontiers in Aging · 126
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An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress
2021 · Julian Nüchel, Marina Tauber, et al. · Molecular Cell · 91
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TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation
2021 · Katharina Fitzian, Anne Brückner, et al. · Molecular Cell · 60
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G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
2021 · Mirja Tamara Prentzell, Ulrike Rehbein, et al. · Cell · 148
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