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Human Aging, Exercise & FMD: Translational Physiology

Funding type: research
Funder scheme: R37
Start date: 1998-02-01
End date: 2014-07-31
Investigator: DOUGLAS R SEALS
Institution: UNIVERSITY OF COLORADO
Funded outputs count: 90
Funder award ID: R37AG013038
OpenAlex ID: G5327450992
Exercise intolerance in heart failure with preserved ejection fraction: Causes, consequences and the journey towards a cure
2023 · Kanokwan Bunsawat, Michael D. Nelson, et al. · Experimental Physiology · 13
Dietary Nitrate and Nitric Oxide Metabolism: Mouth, Circulation, Skeletal Muscle, and Exercise Performance
2020 · Andrew M. Jones, Anni Vanhatalo, et al. · Medicine & Science in Sports & Exercise · 156
Dietary Sodium Restriction Decreases Urinary Ngal in Older Adults with Moderately Elevated Systolic Blood Pressure Free from Chronic Kidney Disease
2020 · Wei Wang, Michel Chonchol, et al. · Journal of Investigative Medicine · 2
Late-life voluntary wheel running reverses age-related aortic stiffness in mice: a translational model for studying mechanisms of exercise-mediated arterial de-stiffening
2020 · Rachel A. Gioscia-Ryan, Zachary S. Clayton, et al. · GeroScience · 25
Aerobic exercise training and vascular function with ageing in healthy men and women
2019 · Douglas R. Seals, Erzsebet E. Nagy, et al. · The Journal of Physiology · 231
Habitual aerobic exercise and circulating proteomic patterns in healthy adults: relation to indicators of healthspan
2018 · Jessica R. Santos-Parker, Keli S. Santos-Parker, et al. · Journal of Applied Physiology · 31
Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue
2018 · Dov B. Ballak, Suzhao Li, et al. · Journal of Biological Chemistry · 52
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Curcumin supplementation and motor-cognitive function in healthy middle-aged and older adults
2018 · Jessica R. Santos-Parker, Kara L. Lubieniecki, et al. · Nutrition and Healthy Aging · 34
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Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function
2017 · Matthew J. Rossman, Rachelle E. Kaplon, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 232
Trehalose supplementation reduces hepatic endoplasmic reticulum stress and inflammatory signaling in old mice
2017 · Michael J. Pagliassotti, Andrea L. Estrada, et al. · The Journal of Nutritional Biochemistry · 57
Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress
2017 · Jessica R. Santos-Parker, Talia R. Strahler, et al. · Aging · 214
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Voluntary aerobic exercise increases arterial resilience and mitochondrial health with aging in mice
2016 · Rachel A. Gioscia-Ryan, Micah L. Battson, et al. · Aging · 61
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Habitual aerobic exercise does not protect against micro- or macrovascular endothelial dysfunction in healthy estrogen-deficient postmenopausal women
2016 · Jessica R. Santos-Parker, Talia R. Strahler, et al. · Journal of Applied Physiology · 69
Nutrition and other lifestyle influences on arterial aging
2016 · Thomas J. LaRocca, Christopher R. Martens, et al. · Ageing Research Reviews · 83
Dietary rapamycin supplementation reverses age‐related vascular dysfunction and oxidative stress, while modulating nutrient‐sensing, cell cycle, and senescence pathways
2016 · Lisa A. Lesniewski, Douglas R. Seals, et al. · Aging Cell · 166
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Practical alternatives to chronic caloric restriction for optimizing vascular function with ageing
2016 · Christopher R. Martens, Douglas R. Seals · The Journal of Physiology · 48
Oral trehalose supplementation improves resistance artery endothelial function in healthy middle-aged and older adults
2016 · Rachelle E. Kaplon, Sierra D. Hill, et al. · Aging · 84
Estimated aortic stiffness is independently associated with cardiac baroreflex sensitivity in humans: role of ageing and habitual endurance exercise
2016 · G L Pierce, S A Harris, et al. · Journal of Human Hypertension · 37
Acupuncture plus low-frequency electrical stimulation (Acu-LFES) attenuates denervation-induced muscle atrophy
2015 · Zhen Su (苏震), Li Hu (虎力), et al. · Journal of Applied Physiology · 56
Improved motor and cognitive performance with sodium nitrite supplementation is related to small metabolite signatures: a pilot trial in middle-aged and older adults
2015 · Jamie N. Justice, Lawrence C. Johnson, et al. · Aging · 53
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Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults
2015 · Allison E. DeVan, Lawrence C. Johnson, et al. · Journal of Applied Physiology · 82
Reduced large elastic artery stiffness with regular aerobic exercise in middle-aged and older adults
2015 · Kristen L. Jablonski, Anthony J. Donato, et al. · Journal of Hypertension · 48
Effect of Dietary Sodium Restriction on Human Urinary Metabolomic Profiles
2015 · Kristen L. Jablonski, Jelena Klawitter, et al. · Clinical Journal of the American Society of Nephrology · 20
Oral nitrite therapy improves vascular function in diabetic mice
2015 · Amy L Sindler, Kimberly Cox-York, et al. · Diabetes and Vascular Disease Research · 13
Sodium nitrite supplementation improves motor function and skeletal muscle inflammatory profile in old male mice
2014 · Jamie N. Justice, Rachel A. Gioscia-Ryan, et al. · Journal of Applied Physiology · 31
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