A newly synthesized compound attenuates aging-related renal fibrosis and mitochondrial dysfunction in aging model mice
Description: Aging is a risk factor for many of the diseases and is associated with a decline in mitochondrial function. Recently, we reported that a newly synthesized compound A, increases cellular ATP level and survival of fibroblasts from patients with mitochondrial disease. In this study, we applied this compound to aging mice model. Administration of compound A to the mice model significantly prolonged life-span and attenuated the aging-rerated fibrosis of kidney. In in vitro studies, compound A reduced proton leak in isolated mitochondria from kidney of mice, which suggested that compound A maintain membrane potential to improve the mitochondrial respiration. Metabolome analysis revealed increased citric acid, iso-citric acid and spermidine levels in compound A treated mice, suggesting that these metabolites may candidate as an anti-aging biomarker. These results suggest that compound A could be a novel therapeutic drug for preventing aging associated with mitochondrial dysfunction.
Amount: ¥4,160,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Early-Career Scientists
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Fumika Nanto-Hara
Institution: National Agriculture and Food Research Organization
Funded outputs count: 0
Funder award ID: 18K17917
OpenAlex ID: G2216618014