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R01 DK102598

Funded outputs count: 41
Funder award ID: R01 DK102598
OpenAlex ID: G2225492
Gαz-independent and -dependent Improvements With EPA Supplementation on the Early Type 1 Diabetes Phenotype of NOD Mice
2024 · Rachel J Fenske, Haley N Wienkes, et al. · Journal of the Endocrine Society
The prostaglandin E2 EP3 receptor has disparate effects on islet insulin secretion and content in β-cells in a high-fat diet-induced mouse model of obesity
2024 · Joshua C. Neuman, Austin Reuter, et al. · American Journal of Physiology-Endocrinology and Metabolism · 3
EP3 signaling is decoupled from the regulation of glucose-stimulated insulin secretion in β-cells compensating for obesity and insulin resistance
2023 · Michael D. Schaid, Jeffrey M. Harrington, et al. · Islets · 7
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What the BTBR/J mouse has taught us about diabetes and diabetic complications
2023 · Mark P. Keller, Kelly L. Hudkins, et al. · iScience · 8
Metformin Monotherapy Alters the Human Plasma Lipidome Independent of Clinical Markers of Glycemic Control and Cardiovascular Disease Risk in a Type 2 Diabetes Clinical Cohort
2023 · Benjamin Wancewicz, Yanlong Zhu, et al. · Journal of Pharmacology and Experimental Therapeutics · 9
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Plasma Prostaglandin E2 Metabolite Levels Predict Type 2 Diabetes Status and One-Year Therapeutic Response Independent of Clinical Markers of Inflammation
2022 · Rachel J. Fenske, Alicia M. Weeks, et al. · Metabolites · 17
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Pharmacological blockade of the EP3 prostaglandin E2 receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage
2021 · Karin J. Bosma, Spencer R. Andrei, et al. · Molecular Metabolism · 29
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Prostaglandin EP3 receptor signaling is required to prevent insulin hypersecretion and metabolic dysfunction in a non-obese mouse model of insulin resistance
2021 · Jaclyn A. Wisinski, Austin Reuter, et al. · American Journal of Physiology-Endocrinology and Metabolism · 9
Human Islet Expression Levels of Prostaglandin E 2 Synthetic Enzymes, But Not Prostaglandin EP3 Receptor, Are Positively Correlated with Markers of β-Cell Function and Mass in Nondiabetic Obesity
2021 · Nathan A. Truchan, Rachel J. Fenske, et al. · ACS Pharmacology & Translational Science · 18
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The influence of intermittent hypoxia, obesity, and diabetes on male genitourinary anatomy and voiding physiology
2021 · Lisa L. Abler, Chelsea A. O’Driscoll, et al. · American Journal of Physiology-Renal Physiology · 10
Rat prostaglandin EP3 receptor is highly promiscuous and is the sole prostanoid receptor family member that regulates INS‐1 (832/3) cell glucose‐stimulated insulin secretion
2021 · Harpreet K. Sandhu, Joshua C. Neuman, et al. · Pharmacology Research & Perspectives · 15
Systemic Metabolic Alterations Correlate with Islet-Level Prostaglandin E2 Production and Signaling Mechanisms That Predict β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes
2021 · Michael D. Schaid, Yanlong Zhu, et al. · Metabolites · 24
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Agonist-independent Gαz activity negatively regulates beta-cell compensation in a diet-induced obesity model of type 2 diabetes
2020 · Michael D. Schaid, Cara L. Green, et al. · Journal of Biological Chemistry · 19
Ultrahigh-Resolution Mass Spectrometry-Based Platform for Plasma Metabolomics Applied to Type 2 Diabetes Research
2020 · Yanlong Zhu, Benjamin Wancewicz, et al. · Journal of Proteome Research · 22
Differential Expression of Ormdl Genes in the Islets of Mice and Humans with Obesity
2020 · Hugo Lee, Rachel J. Fenske, et al. · iScience · 17
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A gene expression network analysis of the pancreatic islets from lean and obese mice identifies complement 1q like-3 secreted protein as a regulator of β-cell function
2019 · James E. Koltes, Itika Arora, et al. · Scientific Reports · 13
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Differential Regulation of β‐cell Function by Tonically‐active and Receptor‐activated Gα z : Implications for β‐cell Compensation and Failure
2019 · Michael D Schaid, Jeff Harrington, et al. · The FASEB Journal
Beta‐cell‐specific loss of the inhibitory G protein, Gα z , alters development and pathophysiology of Type 1 Diabetes
2019 · Rachel Fenske, Darby Peter, et al. · The FASEB Journal
Increasing the dietary ratio of omega 3:omega 6 polyunsaturated fatty acids positively impacts inflammation and islet outcomes in Type 1 Diabetes
2019 · Darby Peter, Rachel Fenske, et al. · The FASEB Journal
Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice
2018 · Elizabeth R. De Leon, Jacqueline A. Brinkman, et al. · Scientific Reports · 22
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Targeting dysfunctional beta-cell signaling for the potential treatment of type 1 diabetes mellitus
2018 · Rachel J Fenske, Michelle E Kimple · Experimental Biology and Medicine · 13
Short‐term methionine deprivation improves metabolic health via sexually dimorphic, mTORCI‐independent mechanisms
2018 · Deyang Yu, Shany E. Yang, et al. · The FASEB Journal · 98
Restoration of metabolic health by decreased consumption of branched‐chain amino acids
2017 · Nicole E. Cummings, Elizabeth M. Williams, et al. · The Journal of Physiology · 340
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The EP3 Receptor/Gz Signaling Axis as a Therapeutic Target for Diabetes and Cardiovascular Disease
2017 · Michael D. Schaid, Jaclyn A. Wisinski, et al. · The AAPS Journal · 17
Radiomanganese PET Detects Changes in Functional β-Cell Mass in Mouse Models of Diabetes
2017 · Reinier Hernandez, Stephen A. Graves, et al. · Diabetes · 40
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