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R01-DK090490

Funded outputs count: 40
Funder award ID: R01-DK090490
OpenAlex ID: G2235800192
α/β-Hydrolase Domain Containing 5 Supports Glucose-Stimulated Lipolysis and Insulin Secretion in Pancreatic β-Cells
2026 · Lucy Kim, Siming Liu, et al. · Diabetes
Dual PI3K and HDAC inhibitor, CUDC-907, effectively inhibits endometrial cancer growth in vitro and in vivo
2025 · Xudong Zhang, Vanessa Lazaro-Camp, et al. · Frontiers in Oncology · 3
Alpha/beta Hydrolase Domain Containing 5 Supports Glucose-stimulated Lipolysis and Insulin Secretion in Pancreatic Beta Cells
2025 · Lucy Kim, Siming Liu, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Acute Inhibition of Adipose Triglyceride Lipase by NG497 Dysregulates Insulin and Glucagon Secretion From Human Islets
2025 · Lucy B Kim, Siming Liu, et al. · Endocrinology · 3
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Transcriptional Response to Fasting Studied in the Liver of Mice That Express Phosphorylation Resistant Perilipin 5
2025 · Corinne E Bovee, Ryan P Grandgenett, et al. · Endocrinology · 3
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Utilization of commercial collagens for preparing well-differentiated human beta cells for confocal microscopy
2023 · Brianna R. Brennecke, USeong Yang, et al. · Frontiers in Endocrinology · 4
Editorial: Study of pancreatic islets based on human models to understand pathogenesis of diabetes
2023 · Yumi Imai, Scott A. Soleimanpour, et al. · Frontiers in Endocrinology · 3
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Oxidative stress and impaired insulin secretion in cystic fibrosis pig pancreas
2022 · Yunxia O'Malley, Mitchell C. Coleman, et al. · Advances in Redox Research · 18
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Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes
2022 · Susheel K. Gunasekar, Litao Xie, et al. · Nature Communications · 51
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Lipid Droplets’ Role in the Regulation of β-Cell Function and β-Cell Demise in Type 2 Diabetes
2022 · Xin Tong, Siming Liu, et al. · Endocrinology · 40
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Deciphering regulatory protein activity in human pancreatic islets via reverse engineering of single-cell sequencing data
2021 · Yumi Imai · Journal of Clinical Investigation · 1
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Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy
2021 · Jaeyong Cho, Yoji Tsugawa, et al. · Biochemical and Biophysical Research Communications · 3
A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β cells
2021 · Mark Li, Fan Shao, et al. · Molecular Therapy — Nucleic Acids · 33
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Mitochondrial Efflux of Citrate and Isocitrate Is Fully Dispensable for Glucose-Stimulated Insulin Secretion and Pancreatic Islet β-Cell Function
2021 · Casey J. Bauchle, Kristen E. Rohli, et al. · Diabetes · 24
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My journey from Japan to becoming a physician-scientist in the United States
2021 · Yumi Imai · Journal of Clinical Investigation · 3
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Perilipin 2 downregulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria
2021 · Akansha Mishra, Siming Liu, et al. · JCI Insight · 29
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Genetic deletion of miR-204 improves glycemic control despite obesity in db/db mice
2020 · Ravinder Reddy Gaddam, Young-Rae Kim, et al. · Biochemical and Biophysical Research Communications · 12
L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells
2020 · Jaeyong Cho, Yukio Horikawa, et al. · Communications Biology · 20
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UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner
2020 · Jaeyong Cho, Masaki Hiramoto, et al. · Biochemical and Biophysical Research Communications · 13
Adipose Triglyceride Lipase Is a Key Lipase for the Mobilization of Lipid Droplets in Human β-Cells and Critical for the Maintenance of Syntaxin 1a Levels in β-Cells
2020 · Siming Liu, Joseph A. Promes, et al. · Diabetes · 31
Characterization of Islet Leukocyte Populations in Human and Murine Islets by Flow Cytometry
2019 · Matthew J. Butcher, Michelle B. Trevino, et al. · Methods in molecular biology · 2
Lentiviral Mediated Gene Silencing in Human Pseudoislet Prepared in Low Attachment Plates
2019 · Siming Liu, Mikako Harata, et al. · Journal of Visualized Experiments · 8
Connecting pancreatic islet lipid metabolism with insulin secretion and the development of type 2 diabetes
2019 · Yumi Imai, Ryan S. Cousins, et al. · Annals of the New York Academy of Sciences · 94
Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications
2018 · A.D. Dobrian, M.A. Morris, et al. · Pharmacology & Therapeutics · 68
Delivery of shRNA via lentivirus in human pseudoislets provides a model to test dynamic regulation of insulin secretion and gene function in human islets
2018 · Mikako Harata, Siming Liu, et al. · Physiological Reports · 20
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