Award

R01-AG024379

Funded outputs count: 44

Funder award ID: R01-AG024379

OpenAlex ID: G2244010748

ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism

2021 · Jie Li, Phillip M. Galbo, et al. · Nature Communications · 39

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The first human trial of CRISPR-based cell therapy clears safety concerns as new treatment for late-stage lung cancer

2020 · Shenghui He · Signal Transduction and Targeted Therapy · 38

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Cells exhibiting strong p16 INK4a promoter activation in vivo display features of senescence

2019 · Jie-Yu Liu, George P. Souroullas, et al. · Proceedings of the National Academy of Sciences · 306

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Expression of p16 INK 4a is a biomarker of chondrocyte aging but does not cause osteoarthritis

2018 · Brian O. Diekman, Garrett A. Sessions, et al. · Aging Cell · 158

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CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

2017 · Jiehui Deng, Eric S. Wang, et al. · Cancer Discovery · 770

Senescence in Health and Disease

2017 · Shenghui He, Norman E. Sharpless · Cell · 1,766

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Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion

2017 · Shenghui He, Patrick J. Roberts, et al. · Science Translational Medicine · 159

Lkb1 deletion in murine B lymphocytes promotes cell death and cancer

2017 · George P. Souroullas, Yuri Fedoriw, et al. · Experimental Hematology · 6

Concentrations of Pro-Inflammatory Cytokines Are Not Associated with Senescence Marker p16INK4a or Predictive of Intracellular Emtricitabine/Tenofovir Metabolite and Endogenous Nucleotide Exposures in Adults with HIV Infection

2016 · Brian M. Maas, Owen Francis, et al. · PLoS ONE · 5

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Population Pharmacokinetics Modeling of Unbound Efavirenz, Atazanavir, and Ritonavir in HIV‐Infected Subjects With Aging Biomarkers

2016 · JB Dumond, J Chen, et al. · CPT Pharmacometrics & Systems Pharmacology · 12

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p16INK4a, a Senescence Marker, Influences Tenofovir/Emtricitabine Metabolite Disposition in HIV‐Infected Subjects

2016 · JB Dumond, JW Collins, et al. · CPT Pharmacometrics & Systems Pharmacology · 6

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Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

2016 · Marco Demaria, Monique N. O'Leary, et al. · Cancer Discovery · 1,336

Sustained p16INK4a expression is required to prevent IR-induced tumorigenesis in mice

2016 · L Palacio, V Krishnan, et al. · Oncogene · 7

Chemotherapy and Stem Cell Transplantation Increase p16 INK4a Expression, a Biomarker of T-cell Aging

2016 · William A. Wood, Janakiraman Krishnamurthy, et al. · EBioMedicine · 69

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An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation

2016 · George P Souroullas, William R Jeck, et al. · Nature Medicine · 212

Role of senescence marker p16INK4a measured in peripheral blood T-lymphocytes in predicting length of hospital stay after coronary artery bypass surgery in older adults

2015 · Aliaksei Pustavoitau, Viachaslau Barodka, et al. · Experimental Gerontology · 36

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

2015 · Jianhui Chang, Yingying Wang, et al. · Nature Medicine · 1,819

Tenofovir/Emtricitabine Metabolites and Endogenous Nucleotide Exposures are associated with p16 INK4a Expression in Subjects on Combination Therapy

2015 · Julie B Dumond, Owen Francis, et al. · Antiviral Therapy · 5

Forging a signature of in vivo senescence

2015 · Norman E. Sharpless, Charles J. Sherr · Nature reviews. Cancer · 1,104

mTOR Signaling in Melanoma: Oncogene-Induced Pseudo-Senescence?

2015 · George P. Souroullas, Norman E. Sharpless · Cancer Cell · 11

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Defining the toxicology of aging

2014 · Jessica A. Sorrentino, Hanna K. Sanoff, et al. · Trends in Molecular Medicine · 67

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Loss of Arp2/3 induces an NF-κB–dependent, nonautonomous effect on chemotactic signaling

2013 · Congying Wu, Elizabeth M. Haynes, et al. · The Journal of Cell Biology · 49

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p16INK4a reporter mice reveal age-promoting effects of environmental toxicants

2013 · Jessica A. Sorrentino, Janakiraman Krishnamurthy, et al. · Journal of Clinical Investigation · 85

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p16INK4a protects against dysfunctional telomere–induced ATR-dependent DNA damage responses

2013 · Yang Wang, Norman Sharpless, et al. · Journal of Clinical Investigation · 48

Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

2013 · Christin E. Burd, Jessica A. Sorrentino, et al. · Cell · 419

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