A new approach for avoiding age-related risks after extended hepatectomy by targeting Pin1.
Description: Liver regeneration was suppressed and the incidence of severe postoperative complications was increased in elderly patients after extended hepatectomy. In vivo, NF-kappaB and STAT3 activation was suppressed in aged mice after extended hepatectomy, resulted in delayed liver regeneration. Pin1 was essential for NF-kappaB and STAT3 activation after hepatectomy. Moreover, Pin1 was decreased in aged mice after extended hepatectomy, resulting in delayed liver regeneration in aged mice. In vitro, knockdown of Pin1 in mice normal hepatocytes, AML-12, inhibited hepatocyte proliferation. Therefore, decreased expression of Pin1 in the elderly patients after extended hepatectomy is the main factor for delayed liver regeneration after extended hepatectomy.
Amount: ¥4,680,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2017-04-01
End date: 2020-03-31
Investigator: Satoshi Kuboki
Institution: Chiba University
Funded outputs count: 1
Funder award ID: 17K10661
OpenAlex ID: G2247355590