Excision Repair of Environmental Telomere Damage
Description: Telomere maintenance is essential for genome stability and the prevention of cancer and degenerative diseases. The proposed research will examine how environmental genotoxic and oxidative stress cause accelerated telomere shortening, and the pathways that preserve damaged telomeres. This project will reveal how various forms of telomeric DNA damage impact telomere function, cellular function and organism health.
Funding type: research
Funder scheme: R35
Start date: 2019-06-01
End date: 2027-04-30
Investigator: PATRICIA L OPRESKO
Institution: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
Funded outputs count: 38
Funder award ID: R35ES030396
OpenAlex ID: G9000874527