Get started
Award

Single Gene Mutants That Confer Longevity in Drosophila

Funding type: research
Funder scheme: R01
Start date: 1999-04-01
End date: 2004-09-30
Investigator: STEPHEN L. HELFAND
Institution: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
Funded outputs count: 26
Funder award ID: R01AG016667
OpenAlex ID: G7329972571
Sirt4 is a mitochondrial regulator of metabolism and lifespan in Drosophila melanogaster
2018 · Jason G. Wood, Bjoern Schwer, et al. · Proceedings of the National Academy of Sciences · 83
The human longevity gene homolog INDY and interleukin‐6 interact in hepatic lipid metabolism
2017 · Christian von Loeffelholz, Stefanie Lieske, et al. · Hepatology · 70
PDF
A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan
2016 · Brian C. Jones, Jason G. Wood, et al. · Nature Communications · 130
PDF
Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila
2016 · Jason G. Wood, Brian C. Jones, et al. · Proceedings of the National Academy of Sciences · 215
Dietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster
2014 · Rachel Whitaker, M. Pilar Gil, et al. · Aging · 58
PDF
Transcriptional response to dietary restriction in Drosophila melanogaster
2014 · Feifei Ding, M. Pilar Gil, et al. · Journal of Insect Physiology · 16
Indy gene variation in natural populations confers fitness advantage and life span extension through transposon insertion
2014 · Chen-Tseh Zhu, Chengyi Chang, et al. · Aging · 18
Dietary and genetic effects on age-related loss of gene silencing reveal epigenetic plasticity of chromatin repression during aging
2013 · Nan Jiang, Guyu Du, et al. · Aging · 54
RNA editing regulates transposon-mediated heterochromatic gene silencing
2013 · Yiannis A. Savva, James E. C. Jepson, et al. · Nature Communications · 53
PDF
Increased expression of Drosophila Sir 2 extends life span in a dose-dependent manner
2013 · Rachel Whitaker, Shakeela Faulkner, et al. · Aging · 103
Indy Mutations and Drosophila Longevity
2013 · Blanka Rogina, Stephen L. Helfand · Frontiers in Genetics · 31
PDF
Chromatin structure and transposable elements in organismal aging
2013 · Jason G. Wood, Stephen L. Helfand · Frontiers in Genetics · 127
PDF
takeout-dependent longevity is associated with altered Juvenile Hormone signaling
2012 · Khalil H. Chamseddin, Sabina Q. Khan, et al. · Mechanisms of Ageing and Development · 40
New comparative genomics approach reveals a conserved health span signature across species
2011 · Michael Antosh, David Fox, et al. · Aging · 18
PDF
Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension inDrosophila
2011 · Michael Antosh, Rachel Whitaker, et al. · Cell Cycle · 31
Chromatin remodeling in the aging genome of Drosophila
2010 · Jason G. Wood, Sara Hillenmeyer, et al. · Aging Cell · 192
PDF
Comparative transcriptional profiling identifies takeout as a gene that regulates life span
2010 · Johannes Bauer, Michael Antosh, et al. · Aging · 63
PDF
Dominant-negative Dmp53 extends life span through the dTOR pathway in D. melanogaster
2010 · Johannes H. Bauer, Chengyi Chang, et al. · Mechanisms of Ageing and Development · 12
Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan
2009 · Yih-Woei C. Fridell, Melissa Hoh, et al. · Aging · 75
PDF
Long-lived Indy and calorie restriction interact to extend life span
2009 · Pei-Yu Wang, Nicola Neretti, et al. · Proceedings of the National Academy of Sciences · 108
Long-lived Indy induces reduced mitochondrial reactive oxygen species production and oxidative damage
2009 · Nicola Neretti, Pei-Yu Wang, et al. · Proceedings of the National Academy of Sciences · 75
dSir2 and Dmp53 interact to mediate aspects of CR-dependent life span extension in D. melanogaster
2008 · Johannes H. Bauer, Siti Nur Sarah Morris, et al. · Aging · 97
Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling
2007 · Johannes H. Bauer, Chengyi Chang, et al. · Proceedings of the National Academy of Sciences · 66
Involvement of Drosophila Uncoupling Protein 5 in Metabolism and Aging
2005 · Adolfo Sánchez-Blanco, Yih-Woei C Fridell, et al. · Genetics · 53
PDF
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
2004 · Blanka Rogina, Stephen L. Helfand · Proceedings of the National Academy of Sciences · 1,361
Year
Topic