Investigating nucleo-cytoplasmic partitioning in Alzheimer's disease and aging
Description: PROJECT NARRATIVE Functional and specific partitioning of proteins between the nucleus and the cytoplasm has emerged as key modulators of nucleolar function, ribosomal dynamics, proteostasis and aging. As such, regulators of nucleo-cytoplasmic partitioning constitute potential targets to treat Alzheimer’s disease and aging. Our proposed research has particular significance to public health as it aims to uncover new modulators of nucleolar and ribosomal function to improve proteostasis and lifespan.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R21
Start date: 2020-08-01
End date: 2023-04-30
Investigator: LOUIS RENE LAPIERRE
Institution: BROWN UNIVERSITY
Funded outputs count: 5
Funder award ID: R21AG068922
OpenAlex ID: G3860779024