Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema
Description: PUBLIC HEALTH RELEVANCE: This study will use dual energy x-ray computed tomography (DECT) to evaluate the relationship between heterogeneous perfusion, hypoxia (low oxygen in inspired gas) and induction of pulmonary vascular dilatation to characterize emphysema susceptibility in a normal smoking population. We will correlate DECT measures of perfusion with lung injury measured by single photon emission computed tomography (SPECT). We will study the effect of pulmonary arterial vasodilation to see if it eliminates indices of persistent lng injury in smokers that are susceptible to emphysema
Funding type: research
Funder scheme: R01
Start date: 2016-03-01
End date: 2022-05-31
Investigator: ERIC ALFRED HOFFMAN
Institution: UNIVERSITY OF IOWA
Funded outputs count: 30
Funder award ID: R01HL130883
OpenAlex ID: G6505653383