Award

Inflammation and Aging-associated Diabetes

Description: Project Narrative This project details a study that will lead to the elucidation of the molecular mechanisms underlying aging-associated chronic inflammation. This study will have profound implications in drug development for aging associated diseases, such as diabetes.

Funder: National Institute on Aging

Funding type: research

Funder scheme: R01

Start date: 2019-08-01

End date: 2026-04-30

Investigator: DANICA CHEN

Institution: UNIVERSITY OF CALIFORNIA BERKELEY

Funded outputs count: 20

Funder award ID: R01AG063389

OpenAlex ID: G8346631816

Late-life semaglutide treatment slows ageing and extends lifespan in female mice

2026 · Yufan Feng, Marine Barthez, et al. · Nature · 5

Trained immunity links hematopoietic stem cell aging to aging-associated inflammation

2026 · Wei-Chieh Mu, Marine Barthez, et al. · Nature Aging · 3

SIRT2 and NAD + Boosting Broadly Suppress Aging‐Associated Inflammation

2025 · Marine Barthez, Zehan Song, et al. · Aging Cell · 9

Nicotinic acid riboside maintains NAD+ homeostasis and ameliorates aging-associated NAD+ decline

2025 · Won-Suk Song, Xiyu Shen, et al. · Cell Metabolism · 17

SIRT2 suppresses aging-associated cGAS activation and protects aged mice from severe COVID-19

2025 · Marine Barthez, Biyun Xue, et al. · Cell Reports · 12

Regulation of Stem Cell Function by NAD +

2025 · Yufan Feng, Huixian Qiu, et al. · Physiology · 3

Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

2024 · Yu-Xuan Lyu, Qiang Fu, et al. · Aging · 45

An NAD+-dependent metabolic checkpoint regulates hematopoietic stem cell activation and aging

2024 · Zehan Song, Sang Hee Park, et al. · Nature Aging · 49

Mitochondrial regulation in stem cells

2023 · Yifei Wang, Marine Barthez, et al. · Trends in Cell Biology · 51

The mitochondrial unfolded protein response regulates hippocampal neural stem cell aging

2023 · Chih-Ling Wang, Rika Ohkubo, et al. · Cell Metabolism · 70

The hepatic integrated stress response suppresses the somatotroph axis to control liver damage in nonalcoholic fatty liver disease

2022 · Rika Ohkubo, Wei-Chieh Mu, et al. · Cell Reports · 24

The therapeutic promises of NAD+ boosters

2021 · Claudia Montllor-Albalate, Zehan Song, et al. · Cell Metabolism · 9

Redox signaling in stem cells and implications for regenerative medicine

2021 · Danica Chen · Free Radical Biology and Medicine · 2

Stem Cell Metabolism and Diet

2020 · Marine Barthez, Zehan Song, et al. · Current Stem Cell Reports · 3

The inherent challenges of classifying senescence—Response

2020 · Stuart R. G. Calimport, Barry L. Bentley, et al. · Science · 5

The mitochondrial metabolic checkpoint in stem cell aging and rejuvenation

2020 · Wei-Chieh Mu, Rika Ohkubo, et al. · Mechanisms of Ageing and Development · 22

An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance

2020 · Ming He, Hou-Hsien Chiang, et al. · Cell Metabolism · 425

Latest advances in aging research and drug discovery

2019 · Daniela Bakula, Andrea Ablasser, et al. · Aging · 27

To help aging populations, classify organismal senescence

2019 · Stuart R. G. Calimport, Barry L. Bentley, et al. · Science · 67

The Epigenetics of Stem Cell Aging Comes of Age

2019 · Danica Chen, Candace Kerr · Trends in Cell Biology · 61