How Does a Young Extracellular Matrix Rejuvenate Old Mesenchymal Stem Cells?
Description: According to the 2010 National Survey of Veteran Enrollees' Health and Reliance on VA, 45% of US Veteran population is 65 years or older, creating a major challenge for treating a large number of age-related diseases. The purpose of this application is to study whether adult mesenchymal stem cells (MSCs) undergo functional and molecular changes because of aging or aging is due to extrinsic environmental factors without any effect on the MSCs. The information gained from this study will lay the foundation to further study of the molecular complexity and dynamics of cell- extracellular matrix adhesions in regulation of MSC proliferation, survival, differentiation and migration, and will facilitate autologous stem cell-baed therapeutic applications.
Funding type: grant
Funder scheme: I01
Start date: 2013-10-01
End date: 2017-09-30
Investigator: XIAO-DONG CHEN
Institution: SOUTH TEXAS VETERANS HEALTH CARE SYSTEM
Funded outputs count: 6
Funder award ID: 1i01bx002145-01
OpenAlex ID: G2342014360