Tissue-specific Mechanism of Action of the Metabolic Hormones FGF19 and FGF21
Description: PUBLIC HEALTH RELEVANCE: While the hormones FGF19 and FGF21 have powerful beneficial effects in obese animals, including increased energy expenditure and weight loss and improved insulin sensitivity, their mechanism of action is poorly understood. The proposed studies will provide important insights into the tissues and molecular pathways whereby FGF19 and FGF21 mediate their powerful metabolic effects and aid in the design of more efficacious clinical derivatives.
Funding type: research
Funder scheme: R01
Start date: 2004-03-01
End date: 2020-03-31
Investigator: STEVEN A. KLIEWER
Institution: UT SOUTHWESTERN MEDICAL CENTER
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 46
Funder award ID: R01DK067158
OpenAlex ID: G8189809066