Multiplexed bio-imaging mass spectrometry
Description: This project aims to develop technology for simultaneous three-dimensional imaging of trace elements and molecules in biological tissues. This technology is an essential analytical and diagnostic advance to uncover latent mechanistic biology and will reveal subtle metabolic interactions between cells. The project will use laser ablation-inductively coupled plasma-mass spectrometry and lanthanide-conjugated probes to map the zinc metabolic pathway in the ageing mouse brain. It is expected to result in a complete imaging solution for quantitative spatial determination of all important elements, co-factors, metabolites and other functional molecules to investigate metabolic pathways which current technologies find difficult or impossible to track. Ultimately this technology is expected to underpin investigations of diseases where trace metal and chemical species dysfunction is implicated.
Funder: Australian Research Council
Amount: A$436,200
Funding type: research
Funder scheme: Discovery Projects
Start date: 2017-01-01
End date: 2020-07-31
Investigator: Philip Doble
Institution: University of Technology Sydney
Funded outputs count: 14
Funder award ID: DP170100036
OpenAlex ID: G241827226