Parathyroid Hormone and Cardiometabolic Outcomes in Obesity: Role of Magnesium and Vitamin D Supplementation
Description: Obesity is one of the leading risk factors for cardiovascular disease (CVD) and several hormonal alterations may contribute this higher risk. For example, obesity is associated with higher levels of serum parathyroid hormone (sPTH) that is an independent risk factor for CVD. This proposal will examine whether dietary interventions to decrease sPTH levels will be associated with reductions in CVD risk. Magnesium (Mg) and vitamin D (vit D) status are important regulators of sPTH levels and previous studies show that supplementation with either Mg or vitamin D can reduce PTH levels in normal weight individuals. Obesity is associated with both Mg and vit D deficiency and thus, this study will address whether repleting magnesium status in addition to vitamin D status will reduce sPTH levels in obese individuals. More importantly we will examine whether a reduction in sPTH levels is associated with improvements in cardiometabolic risk factors such as serum lipids, pro-inflammatory cytokines, blood pressure and glycemic indices. One hundred twenty three participants aged 30-60 years will be enrolled in a 12 week clinical trial and participants will be randomized to one of the 3 treatment groups ' 1) Vit D, 2) Vit D+Mg 3) Placebo. Biochemical markers such as serum levels of PTH, 25 hydroxy vitamin D, serum indicators of magnesium status, lipid profile pro-inflammatory cytokines and glycemic indices will be assessed at baseline, wk-6 and wk-12 of the study. We hypothesize that the Mg+D group will observe the greatest reductions in sPTH levels. Furthermore we hypothesize that the reduced sPTH level will be associated with favorable changes in CVD risk factors such as decreases in serum lipids, blood pressure pro inflammatory cytokines and glycemic indices. This approach will provide a non-pharmacological, non-surgical, cost effective and simple means to reduce sPTH levels in the obese population, thereby lowering their cardiovascular risk.
Funder: American Heart Association
Amount: $308,000
Funding type: fellowship
Funder scheme: Scientist Development Grant
Start date: 2016-01-01
End date: 2019-12-31
Investigators: Deeptha Sukumar, Deeptha Sukumar
Institution: Drexel University
Funded outputs count: 4
Funder award ID: 16SDG27050002
OpenAlex ID: G2425378073