Expressão de TNFR1, VEGFA, CD147 e MCT1 como biomarcadores precoces de complicações do diabetes e o impacto do envelhecimento nesse perfil.
Description: Hyperglycemia leads to microvascular lesions in various tissues. In diabetic nephropathy - DN,alterations in usual markers reflect an already installed disease. The study of new biomarkersfor the early detection of diabetic complications can bring new prevention perspectives. Ratswere divided into diabetic adult - DMA - or elderly - DME and control sham adult - CSA -or control sham elderly - CSE. Blood and urine samples were collected for biochemicalanalysis. Bulbar region, cardiac, hepatic and renal tissues were collected for target geneexpression studies. As result, DMA showed decreased TNFR1, MCT1 and CD147 expressionin the bulbar region, TNFR1 in the heart, VEGFA and CD147 in the kidney and TNFR1 in blood.Positive correlations were found between TNFR1 and MCT1 in the bulbar region and HbA1cand plasma creatinine, respectively. DME showed positive correlation in the bulbar regionbetween TNFR1 and glycemia, in addition to negative correlations between CD147 in the heartversus glycemia and urea. We concluded that the initial hyperglycemic stimulus alreadypromotes changes in the expression of genes involved in the inflammatory and metabolicpathways, and aging alters this profile. These changes prior to the onset of diseases such as DN,show that they have potential for early biomarkers studies. (AU)
Funding type: publication
Funder scheme: Auxílio à Pesquisa - Publicações científicas - Artigo
Start date: 2023-10-01
End date: 2024-03-31
Investigator: Glaucia Raquel Luciano da Veiga
Institution: Centro Universitário FMABC (FMABC)
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 0
Funder award ID: 23/11757-7
OpenAlex ID: G2450178880