Mechanism of immune cell inactivation using glioma stem cells and iPS cells
Description: To search for factors that influence recurrence and prognosis of glioblastoma, we characterized a chemotherapy-resistant stem cell line and tested the effects of immunotherapy using a mouse model. The stem cells expressed the immune checkpoint molecule PD-L1. In addition, expression of some factors related to macrophage induction and differentiation are observed. The combination of anti-PD-L1 antibody and immunosuppressive macrophage inhibitors in a mouse subcutaneous tumor model prolonged survival time by suppressing macrophage infiltration after immunotherapy. Also in human glioblastoma, infiltrating macrophages were increased in early recurrent tissues after immunotherapy, suggesting that they may contribute to the recurrence of the disease. Based on these experiences, we made research papers and review articles.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2023-03-31
Investigator: Eiichi Ishikawa
Institution: University of Tsukuba
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Funded outputs count: 5
Funder award ID: 18K08962
OpenAlex ID: G2451736096