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Cardioprotective mechanisms in aging

Description: Hypertrophy; Autophagy; Heart Failure; Aging
Amount: €350,000
Funding type: grant
Funder scheme: Einzelprojekte
Start date: 2015-02-01
End date: 2018-11-30
Funded outputs count: 7
Funder award ID: P 27637
OpenAlex ID: G2463494447
A surge in endogenous spermidine is essential for rapamycin-induced autophagy and longevity
2024 · Sebastian J. Hofer, Ioanna Daskalaki, et al. · Autophagy · 25
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Antagonistic pleiotropy: the example of cardiac insulin-like growth factor signaling, which is essential in youth but detrimental in age
2023 · Mahmoud Abdellatif, Frank Madeo, et al. · Expert Opinion on Therapeutic Targets · 7
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Cardiac PI3K p110α attenuation delays aging and extends lifespan
2022 · Mahmoud Abdellatif, Tobias Eisenberg, et al. · Cell Stress · 8
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Cardioprotection by spermidine does not depend on structural characteristics of the myocardial microcirculation in aged mice
2019 · Marie-Christin Wierich, Julia Schipke, et al. · Experimental Gerontology · 6
Cardioprotective effects of autophagy induction in sepsis
2018 · Mahmoud Abdellatif, Simon Sedej, et al. · Annals of Translational Medicine · 12
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Ketone bodies to the rescue for an aging heart?
2017 · Simon Sedej · Cardiovascular Research · 20
Cardioprotection and lifespan extension by the natural polyamine spermidine
2016 · Tobias Eisenberg, Mahmoud Abdellatif, et al. · Nature Medicine · 1,168
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