Reprogramming macrophage function in the elderly to rescue impaired inflammatory responses to muscle injury
Description: Muscle injury in the elderly often takes longer to heal than in younger people, however the cells responsible for this delayed healing are not well understood. Key inflammatory cells required for muscle repair in young hosts are macrophages. However, during aging we have shown that macrophage function is altered, but the mechanism is unknown. This project aims to determine the mechanisms behind age-related changes to macrophages and whether they can be targeted to improve elderly muscle repair.
Amount: A$411,000
Funding type: research
Funder scheme: Project Grants - New Investigator Grant
Start date: 2016-01-01
End date: 2018-12-31
Investigator: Connie Jackaman
Institution: Curtin University of Technology
Funded outputs count: 2
Funder award ID: 1100803
OpenAlex ID: G2475397078