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Kidney Function, Aortic Stiffness and Aging

Description: Chronic kidney disease is a common problem in the elderly that is associated with an increased risk for kidney failure, complications of low kidney function and disease of the heart and blood vessels. Kidney function goes down with age but the cause is not completely understood and is thought to be related to high blood pressure caused by stiffening of the aorta that occurs with aging. This study will measure kidney function and stiffening of the aorta in a group of community dwelling older adults.
Funding type: research
Funder scheme: R01
Start date: 2010-05-01
End date: 2016-04-30
Investigator: ANDREW S LEVEY (lead)
Field: Medicine
Funded outputs count: 40
Funder award ID: R01DK082447
OpenAlex ID: G3644375880
Associations of Brain Structure and Neuropsychological Function With Artificial Intelligence Estimates of Biological Vascular Age
2026 · Leroy L. Cooper, Ayantika Banerjee, et al. · Arteriosclerosis Thrombosis and Vascular Biology
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Interrelations of aortic spring function, cardiovascular disease risk factors, and left ventricular diastolic function: The Framingham Heart Study
2026 · Leroy L. Cooper, Brenton R. Prescott, et al. · Physiological Reports
Associations of noninvasive measures of adiposity with aortic stiffness and microvascular function: The Jackson Heart Study
2026 · Carey R. Williams, Brielle Quarles, et al. · American Journal of Preventive Cardiology · 1
Relations of AI-Vascular Age Estimated From a Peripheral Pressure Waveform With Incident Atrial Fibrillation: The Framingham Heart Study
2025 · Timothy J. Korzinski, Celestin Hategeka, et al. · Circulation Arrhythmia and Electrophysiology
CKD-EPI and EKFC GFR Estimating Equations: Performance and Other Considerations for Selecting Equations for Implementation in Adults
2023 · Lesley A. Inker, Hocine Tighiouart, et al. · Journal of the American Society of Nephrology · 60
Relations of postural change in blood pressure with hypertension-mediated organ damage in middle-aged adults of the Framingham heart study: A cross-sectional study
2022 · Leroy L. Cooper, Jian Rong, et al. · Frontiers in Cardiovascular Medicine · 3
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New Creatinine- and Cystatin C–Based Equations to Estimate GFR without Race
2021 · Lesley A. Inker, Nwamaka D. Eneanya, et al. · New England Journal of Medicine · 5,231
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Kidney Function and Aortic Stiffness, Pulsatility, and Endothelial Function in African Americans: The Jackson Heart Study
2021 · Harsha S. Nagarajarao, Solomon K. Musani, et al. · Kidney Medicine · 12
Relations of arterial stiffness and endothelial dysfunction with incident venous thromboembolism
2021 · Darae Ko, Sarah R. Preis, et al. · Thrombosis Research · 5
A New Panel-Estimated GFR, Including β2-Microglobulin and β-Trace Protein and Not Including Race, Developed in a Diverse Population
2020 · Lesley A. Inker, Sara J. Couture, et al. · American Journal of Kidney Diseases · 82
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Comparability of Plasma Iohexol Clearance Across Population-Based Cohorts
2019 · Bjørn O. Eriksen, Elke Schaeffner, et al. · American Journal of Kidney Diseases · 15
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Carotid Flow Velocities and Blood Pressures Are Independently Associated With Cognitive Function
2018 · Shao-Yuan Chuang, Hao-Min Cheng, et al. · American Journal of Hypertension · 16
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Comparison of glomerular filtration rate estimating equations derived from creatinine and cystatin C: validation in the Age, Gene/Environment Susceptibility-Reykjavik elderly cohort
2017 · Jonas Björk, Anders Grubb, et al. · Nephrology Dialysis Transplantation · 49
Prevalence, Correlates, and Prognosis of Healthy Vascular Aging in a Western Community-Dwelling Cohort: The Framingham Heart Study
2017 · Teemu J. Niiranen, Asya Lyass, et al. · Hypertension · 131
Non-GFR Determinants of Low-Molecular-Weight Serum Protein Filtration Markers in the Elderly: AGES-Kidney and MESA-Kidney
2017 · Meredith C. Foster, Andrew S. Levey, et al. · American Journal of Kidney Diseases · 80
Microvascular Function Contributes to the Relation Between Aortic Stiffness and Cardiovascular Events: The Framingham Heart Study
2016 · Leroy L. Cooper, Joseph N. Palmisano, et al. · Circulation Cardiovascular Imaging · 101
Ethnic Difference in Proximal Aortic Stiffness
2016 · Akshay Goel, Christopher D. Maroules, et al. · JACC. Cardiovascular imaging · 55
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Associations between arterial stiffness, depressive symptoms and cerebral small vessel disease: cross-sectional findings from the AGES-Reykjavik Study
2016 · Thomas T. van Sloten, Gary F. Mitchell, et al. · Journal of Psychiatry and Neuroscience · 66
Circulating Adipokines and Vascular Function: Cross-Sectional Associations in a Community-Based Cohort
2015 · Justin P. Zachariah, Susan Hwang, et al. · Hypertension · 43
Cerebrovascular Damage Mediates Relations Between Aortic Stiffness and Memory
2015 · Leroy L. Cooper, Todd Woodard, et al. · Hypertension · 153
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Prevalence and complications of chronic kidney disease in a representative elderly population in Iceland
2015 · Aghogho Okparavero, Meredith C. Foster, et al. · Nephrology Dialysis Transplantation · 22
GFR Estimation Using β-Trace Protein and β2-Microglobulin in CKD
2015 · Lesley A. Inker, Hocine Tighiouart, et al. · American Journal of Kidney Diseases · 156
Higher Plasma Phospholipid n–3 PUFAs, but Lower n–6 PUFAs, Are Associated with Lower Pulse Wave Velocity among Older Adults
2015 · Ilse Reinders, Rachel A Murphy, et al. · Journal of Nutrition · 25
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Lifetime Risk of Stage 3–5 CKD in a Community-Based Sample in Iceland
2015 · Lesley A. Inker, Hocine Tighiouart, et al. · Clinical Journal of the American Society of Nephrology · 32
Influence of Vascular Function and Pulsatile Hemodynamics on Cardiac Function
2015 · Vanessa Bell, Gary F. Mitchell · Current Hypertension Reports · 34