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Comparative Bioenergetics of Aging

Description: Project Narrative The University of Alabama at Birmingham Nathan Shock Center of Excellence in the Basic Biology of Aging will continue to provide state-of-the-art research services and education focused on whole animal as well as cell and tissue level energetics and methods for analyzing these experimental data as they pertain to lifelong health and longevity. It will also provide education and training in geroscience and energetic analyses that are understandable at levels appropriate for the general public to levels appropriate for other scientists, and even scientific specialists in allied fields.
Funding type: program
Funder scheme: P30
Start date: 2015-07-15
End date: 2030-05-31
Subfield: Aging
Funded outputs count: 256
Funder award ID: P30AG050886
OpenAlex ID: G9000890001
Gut microbiome depletion aggravates glial-mediated Alzheimer’s disease pathology through inflammatory, metabolic, and proteostatic dysregulation
2026 · Kishore Madamanchi, Srinath Gurrala, et al. · Gut Microbes
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Chronic non-24-h light–dark cycles alter healthspan measures but not overall survival in male C57BL/6 J mice
2026 · Daniel L. Smith, Victoria K. Gibbs, et al. · GeroScience
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The impact of aging, sex, and exercise on brain mitochondria
2026 · Jianhua Zhang, Victor Darley-Usmar, et al. · Frontiers in Aging
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Metabolic responses to O-GlcNAcase inhibition in AppNL-G-F mice
2026 · Xiaosen Ouyang, Ran Tian, et al. · Advances in Redox Research
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Aging rate indicators and the search for anti-aging drugs
2026 · Steven N. Austad, Matt Kaeberlein, et al. · Frontiers in Science · 4
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Blocking PD-L2 prevents senescent cell accumulation and age-related dysfunction
2026 · Selim Chaib, Larissa G.P. Langhi Prata, et al. · Cell Metabolism
Forced treadmill running and ladder climbing physical activity attenuates cognitive decline and protein aggregates in aged 3xTg-AD mice
2026 · Mingming Yang, Xiaosen Ouyang, et al. · Molecular Brain
Neuronal Syndecan reduction modulates age- and sex-specific changes in sleep architecture and metabolic remodeling in Drosophila melanogaster
2026 · Victoria G. Faber, Denise Vecchie’, et al. · Mechanisms of Ageing and Development
Exercise attenuates obesity-related cognitive and sleep-circadian dysfunctions by attenuating neuroinflammation via JAK/STAT in sex and age specific manner
2026 · Archana Yadav, Morgan Barkley, et al. · International Journal of Obesity · 1
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Small extracellular vesicle signaling and mitochondrial transfer reprogram T helper cell function in human asthma
2026 · Kenneth P. Hough, Jennifer L. Trevor, et al. · Nature Communications · 9
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Innovative CRISPR Etf-QO Mutant Knock-in Model Mimics MADD-associated Lipid Storage Myopathy and Reveal Therapeutic Potential of Exercise Intervention
2026 · Sachin Budhathoki, Yiming Guo, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Vitamin B12 improves skeletal muscle mitochondrial biology in aged mice
2026 · Abigail R. Williamson, Angad Yadav, et al. · GeroScience
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Endogenous oxalate synthesis in mouse models of metabolic dysfunction-associated steatotic liver disease
2026 · Xingsheng Li, Owen P. Cunneely, et al. · American Journal of Physiology-Renal Physiology
Fueling asthma inflammation via bioenergetic metabolic reprogramming
2026 · Anny Mulya, Allison J. Janocha, et al. · Redox Biology · 3
Feasibility of high-intensity interval training in older adults with HIV and co-occurring hypertension
2026 · Michael J. Hankes, Taylor L. Taylor, et al. · Pilot and Feasibility Studies
Reanalyzing Castner et al. confirms most conclusions, reveals additional findings, and detects some statistical errors
2026 · Olivia C. Robertson, Erik Parker, et al. · Journal of Robustness Reports
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Improving statistical rigor in animal aging research by addressing clustering and nesting effects: Illustration with the National Institute on Aging’s Intervention Testing Program data
2026 · Erik S Parker, Lilian Golzarri-Arroyo, et al. · The Journals of Gerontology Series A · 4
Microbes, mood, and metabolism/obesity: Pharmacological insights into the gut-obesity-depression triad
2026 · Archana Yadav, Girish C. Melkani · Cellular and Molecular Life Sciences · 6
Regulation of Lipid Dysmetabolism and Neuroinflammation Progression Linked With Alzheimer's Disease Through Modulation of Dgat2
2026 · Archana Yadav, Xiaosen Ouyang, et al. · Aging Cell · 10
Plasma Biomarkers of Senescence in Cholestatic Liver Disease: A Signature of Risk Stratification and Progression
2026 · Steven P. O'Hara, Pamela Tietz Bogert, et al. · Journal of Gastroenterology and Hepatology · 2
Vitamin B12 Supports Skeletal Muscle Oxidative Phosphorylation Capacity in Male Mice
2026 · Luisa F Castillo, Katarina E Heyden, et al. · Journal of Nutrition · 2
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Selection for Postponed Senescence in Drosophila melanogaster Reveals Distinct Metabolic Aging Trajectories Modifiable by the Angiotensin‐Converting Enzyme Inhibitor Lisinopril
2026 · Denise Vecchié, Robert R. H. Anholt, et al. · Aging Cell · 3
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Impacts of exercise, renin–angiotensin system modulation or both on skeletal muscle circadian gene expression
2026 · Emily L. Zumbro, Liliana C. Baptista, et al. · Experimental Physiology · 1
Association between cagemate number and risk of death in mice: a time-varying covariate analysis using Cox frailty models
2026 · Thirupathi R. Mokalla, Erik S. Parker, et al. · GeroScience
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Uncoupling Insulin Sensitivity From Longevity: A Sex‐Dependent Effect of Hepatic Glucagon Signaling
2026 · Alexander Tate Lasher, Ben Heckman, et al. · Aging Cell
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