Genetic mechanisms of metformin's pro-longevity and anti-cancer effects
Description: Metformin is best known for its role in treating diabetes, but it promotes many other health benefits like inhibiting cancer growth and prolonging lifespan in model organisms. Despite these well described effects, the ways that metformin produces these effects remain unknown, and the highest doses of metformin used today may not be able to maximize these health benefits without undesirable side effects. This project will determine the genes that metformin acts through to produce these benefits, with the ultimate goal of exploiting metformin action to extend lifespan and reduce aging-related diseases such as cancer.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2017-12-01
End date: 2023-11-30
Investigator: ALEXANDER A SOUKAS
Institution: MASSACHUSETTS GENERAL HOSPITAL
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 24
Funder award ID: R01AG058256
OpenAlex ID: G327666152