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The role of neutrophils in the age-driven decline in anti-pneumococcal vaccine responses

Description: Project Narrative: This proposal is designed to uncover the role of neutrophils in the age-driven decline in vaccine efficacy against Streptococcus pneumoniae, the leading cause of community-acquired bacterial pneumonia in the elderly. This will allow identification of novel targets to boost memory responses in the elderly.
Funding type: research
Funder scheme: R01
Start date: 2021-09-30
End date: 2027-05-31
Investigator: ELSA BOU GHANEM
Institution: STATE UNIVERSITY OF NEW YORK AT BUFFALO
Funded outputs count: 13
Funder award ID: R01AG068568
OpenAlex ID: G9000919010
Neutrophils induce effective antibody responses to the pneumococcal conjugate vaccine by inhibiting T regulatory cells
2026 · Essi Y I Tchalla, Anagha Betadpur, et al. · Journal of Leukocyte Biology
Host Aging Induces a Senescent‐Like Phenotype in Neutrophils and Altered Transcriptional Responses to Streptococcus pneumoniae
2026 · Michael C. Battaglia, Manmeet Bhalla, et al. · Aging Cell · 2
Basal activation of ERK1/2 blunts the antimicrobial activity of neutrophils from old hosts against antibody-opsonized Streptococcus pneumoniae
2026 · Shaunna R Simmons, Annabel Rivera, et al. · Journal of Leukocyte Biology · 1
Extracellular adenosine released by mesenchymal stromal cells from young hosts boosts the antimicrobial activity of neutrophils from aged hosts against Streptococcus pneumoniae
2025 · Rania Hassan Mohamed, Michael C Battaglia, et al. · Immunotherapy Advances
Damage response signaling by the extracellular adenosine pathway: control of infection outcome during host aging
2025 · Manmeet Bhalla, Shaunna R. Simmons, et al. · mSphere · 4
Adenosine 2B Receptor Signaling Impairs Vaccine-Mediated Protection Against Pneumococcal Infection in Young Hosts by Blunting Neutrophil Killing of Antibody-Opsonized Bacteria
2025 · Shaunna R. Simmons, Alexsandra P. Lenhard, et al. · Vaccines · 2
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Sex-based difference in immune responses and efficacy of the pneumococcal conjugate vaccine
2024 · Essi Y I Tchalla, Anagha Betadpur, et al. · Journal of Leukocyte Biology · 5
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Activating A1 adenosine receptor signaling boosts early pulmonary neutrophil recruitment in aged mice in response to Streptococcus pneumoniae infection
2024 · Shaunna R. Simmons, Sydney E. Herring, et al. · Immunity & Ageing · 9
The prostaglandin D2 antagonist asapiprant ameliorates clinical severity in young hosts infected with invasive Streptococcus pneumoniae
2024 · Manmeet Bhalla, Sydney Herring, et al. · Infection and Immunity · 1
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Mitochondrial ROS production by neutrophils is required for host antimicrobial function against Streptococcus pneumoniae and is controlled by A2B adenosine receptor signaling
2022 · Sydney E. Herring, Sovathiro Mao, et al. · PLoS Pathogens · 45
A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
2022 · Alexsandra Lenhard, Basma H. Joma, et al. · Journal of Visualized Experiments · 3
The Age-Driven Decline in Neutrophil Function Contributes to the Reduced Efficacy of the Pneumococcal Conjugate Vaccine in Old Hosts
2022 · Shaunna R. Simmons, Essi Y. I. Tchalla, et al. · Frontiers in Cellular and Infection Microbiology · 29
Liposomal Encapsulation of Polysaccharides (LEPS) as an Effective Vaccine Strategy to Protect Aged Hosts Against S. pneumoniae Infection
2021 · Manmeet Bhalla, Roozbeh Nayerhoda, et al. · Frontiers in Aging · 8
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