Thymic adipogenesis and age-related thymic demise
Description: PUBLIC HEALTH RELEVANCE: Thymus produces infection and cancer fighting immune cells called as T-lymphocytes. However, with progressive aging, thymus is replaced with fat cells and its ability to produce T-lymphocytes is dramatically diminished. This research project is designed to understand the origin of fat cells in aging thymus and to determine the causes and consequences of thymic adiposity during aging. The aim of this project is to unravel underlying process of thymic dysfunction that impacts immune function in aging with a long-term goal of developing novel therapeutic approaches to strengthen immunity and enhance health-span of elderly.
Funding type: research
Funder scheme: R01
Start date: 2014-11-01
End date: 2019-10-31
Investigator: VISHWA DEEP DIXIT
Institution: YALE UNIVERSITY
Funded outputs count: 22
Funder award ID: R01AI105097
OpenAlex ID: G8266177506