Get started
Award

Longitudinal Epigenomic Tracking of the Reprogramming Process

Description: Discovering features associated with successful and abortive de-differentiation will form the basis by which reprogramming can be improved, both in efficiency and differentiation potential, by molecular manipulations. This development should bring iPSCs closer for their use in patients for regenerative medicine.
Funding type: program
Funder scheme: P01
Start date: 2011-09-15
End date: 2016-08-31
Investigator: MICHAEL P. SNYDER
Institution: STANFORD UNIVERSITY
Funded outputs count: 58
Funder award ID: P01GM099130
OpenAlex ID: G25486711
Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing
2019 · Salah Mahmoudi, Elena Mancini, et al. · Nature · 285
Cross-Platform Comparison of Untargeted and Targeted Lipidomics Approaches on Aging Mouse Plasma
2018 · Kévin Contrepois, Salah Mahmoudi, et al. · Scientific Reports · 118
PDF
Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a
2018 · Kun-Yong Kim, Yoshiaki Tanaka, et al. · Nature Communications · 66
PDF
Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs
2017 · Ming-Tao Zhao, Haodong Chen, et al. · Proceedings of the National Academy of Sciences · 78
New Advances in Human X Chromosome Status from a Developmental and Stem Cell Biology
2017 · Benjamin Patterson, Yoshiaki Tanaka, et al. · Tissue Engineering and Regenerative Medicine
Cell Type-Specific Chromatin Signatures Underline Regulatory DNA Elements in Human Induced Pluripotent Stem Cells and Somatic Cells
2017 · Ming-Tao Zhao, Ning-Yi Shao, et al. · Circulation Research · 21
PDF
Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods
2017 · Jared M. Churko, Jaecheol Lee, et al. · Nature Biomedical Engineering · 50
Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration
2017 · Yangfei Xiang, Yoshiaki Tanaka, et al. · Cell stem cell · 705
PDF
Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression
2017 · Kévin Contrepois, Clément Coudereau, et al. · Nature Communications · 191
PDF
Dnmt1 regulates the myogenic lineage specification of muscle stem cells
2016 · Renjing Liu, Kun-Yong Kim, et al. · Scientific Reports · 21
PDF
Next-generation molecular diagnosis: single-cell sequencing from bench to bedside
2016 · Wanjun Zhu, Xiao-Yan Zhang, et al. · Cellular and Molecular Life Sciences · 27
iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy
2016 · Kazuki Kodo, Sang-Ging Ong, et al. · Nature Cell Biology · 171
Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro
2016 · Elena Matsa, Paul W. Burridge, et al. · Cell stem cell · 165
PDF
Regulation of the DNA Methylation Landscape in Human Somatic Cell Reprogramming by the miR-29 Family
2016 · Eriona Hysolli, Yoshiaki Tanaka, et al. · Stem Cell Reports · 38
PDF
Effects of cellular origin on differentiation of human induced pluripotent stem cell–derived endothelial cells
2016 · Shijun Hu, Ming-Tao Zhao, et al. · JCI Insight · 74
Single-Cell Sequencing for Precise Cancer Research: Progress and Prospects
2016 · Xiaoyan Zhang, Sadie L. Marjani, et al. · Cancer Research · 122
Systematic Characterization of Long Noncoding RNAs Reveals the Contrasting Coordination of Cis - and Trans -Molecular Regulation in Human Fetal and Adult Hearts
2016 · Chunjiang He, Hanyang Hu, et al. · Circulation Cardiovascular Genetics · 43
Histone Deacetylases Positively Regulate Transcription through the Elongation Machinery
2015 · Celeste B. Greer, Yoshiaki Tanaka, et al. · Cell Reports · 175
PDF
Exosomes as Potential Alternatives to Stem Cell Therapy in Mediating Cardiac Regeneration
2015 · Sang-Ging Ong, Joseph C. Wu · Circulation Research · 88
Transcriptome Signature and Regulation in Human Somatic Cell Reprogramming
2015 · Yoshiaki Tanaka, Eriona Hysolli, et al. · Stem Cell Reports · 28
PDF
Comprehensive transcriptome analysis using synthetic long-read sequencing reveals molecular co-association of distant splicing events
2015 · Hagen Tilgner, Fereshteh Jahanbani, et al. · Nature Biotechnology · 223
46,XY disorders of sex development and congenital diaphragmatic hernia: A case with dysmorphic facies, truncus arteriosus, bifid thymus, gut malrotation, rhizomelia, and adactyly
2015 · Edward D. Esplin, Hassan Chaib, et al. · American Journal of Medical Genetics Part A · 6
Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells
2015 · Edward J. Grow, Ryan A. Flynn, et al. · Nature · 647
MicroRNA-mediated regulation of differentiation and trans-differentiation in stem cells
2015 · Sang-Ging Ong, Won Hee Lee, et al. · Advanced Drug Delivery Reviews · 68
Modeling Cardiovascular Diseases with Patient-Specific Human Pluripotent Stem Cell-Derived Cardiomyocytes
2015 · Paul W. Burridge, Sebastian Diecke, et al. · Methods in molecular biology · 47
Year
Topic