Centrally-linked longitudinal peripheral biomarkers of AD in multi-ethnic populations
Description: Project Narrative (3 sentences): There is a clear and immediate need for the discovery of peripheral molecular signatures linked to central disease processes, core and co-pathologies in Alzheimer’s Disease (AD), that will serve as precision medicine blood-based biomarkers for diagnostic, prognostic, theragnostic and therapeutic purposes. AD is a complex disorder in which many biological pathways are disrupted due to multi-omic perturbations, which can be detected in brain and reflected in blood, i.e. centrally-linked peripheral molecular signatures (CLPMS). This U19 will leverage deeply phenotyped, longitudinal NIH-funded multi-ethnic cohorts and cross-disciplinary expertise for multi-omics data generation and its integration with harmonized AD endophenotypes, will share these data and utilize them in integrated U19 projects to discover CLPMS that will serve as the next generation of AD biomarkers.
Funder: National Institute on Aging
Funding type: cooperative_agreement
Funder scheme: U19
Start date: 2023-03-15
End date: 2028-02-29
Investigator: MINERVA MARIA CARRASQUILLO
Institution: MAYO CLINIC JACKSONVILLE
Funded outputs count: 174
Funder award ID: U19AG074879
OpenAlex ID: G9000907300