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The Role of Enhancer of Zeste Homolog 2 in Cellular Senescence

Description: PUBLIC HEALTH RELEVANCE: Recent evidence suggests that cellular senescence, an irreversible growth arrest, may be involved in organismal aging processes. Age is a large risk factor for many debilitating chronic diseases, and understanding the mechanisms of cellular senescence is expected to lead to therapies to improve human health span (years of healthy living). This proposal will examine the role of epigenetic changes in regulating cellular senescence.

Funder: National Institute on Aging

Funding type: fellowship

Funder scheme: F31

Start date: 2013-07-01

End date: 2016-06-30

Investigator: TAKAHIRO ITO

Institution: BROWN UNIVERSITY

Topic: Telomeres, Telomerase, and Senescence

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

Funded outputs count: 6

Funder award ID: F31AG043189

OpenAlex ID: G7003914099

L1 drives IFN in senescent cells and promotes age-associated inflammation

2019 · Marco De Cecco, Takahiro Ito, et al. · Nature · 1,255

Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways

2018 · Takahiro Ito, Yee Voan Teo, et al. · Cell Reports · 265

Death by transposition – the enemy within?

2013 · John M. Sedivy, Jill A. Kreiling, et al. · BioEssays · 60

The CLAMP protein links the MSL complex to the X chromosome during Drosophila dosage compensation

2013 · Marcela M.L. Soruco, Jessica Chery, et al. · Genes & Development · 130

Docking Interactions of Hematopoietic Tyrosine Phosphatase with MAP Kinases ERK2 and p38α

2012 · Andrea Piserchio, Dana M. Francis, et al. · Biochemistry · 19

Differential Ubiquitination and Proteasome Regulation of Ca V 2.2 N-Type Channel Splice Isoforms

2012 · Spiro Marangoudakis, Arturo Andrade, et al. · Journal of Neuroscience · 43