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Accelerating the diagnosis of bipolar disorder using genetic and phenotypic signatures

Description: PROJECT NARRATIVE Because the majority of patients with bipolar disorder initially manifest depressive symptoms and are misdiagnosed with major depressive disorder, they often receive several years of sub-optimal treatment and experience poor clinical outcomes, until they obtain the correct diagnosis. I aim to identify genetic and phenotypic signatures that predict which patients diagnosed with depression are likely to develop bipolar disorder, which may accelerate diagnosis and reduce the burden of this disorder on patients and society.
Funding type: career_development
Funder scheme: K99
Start date: 2018-04-01
End date: 2020-03-31
Investigator: LOES MARLEIN OLDE LOOHUIS
Institution: UNIVERSITY OF CALIFORNIA LOS ANGELES
Subfield: Genetics
Funded outputs count: 16
Funder award ID: K99MH116115
OpenAlex ID: G5536622645
2025 · Georgia Panagiotaropoulou, Kajsa-Lotta Georgii Hellberg, et al. · The British Journal of Psychiatry · 6
2022 · Rachel M. Brouwer, Marieke Klein, et al. · Nature Neuroscience · 229
2021 · Seidman, L.J., Loohuis, L.O., et al. · Carolina Digital Repository (University of North Carolina at Chapel Hill)
2021 · Janos L. Kalman, Loes M. Olde Loohuis, et al. · The British Journal of Psychiatry · 50
2019 · Diana O. Perkins, Loes Olde Loohuis, et al. · American Journal of Psychiatry · 126
2019 · Claudia L. Satizabal, Hieab H. H. Adams, et al. · Nature Genetics · 260
2019 · Catharine E. Krebs, Anil P.S. Ori, et al. · Psychological Medicine · 44
2019 · Eva Mennigen, Dietsje D Jolles, et al. · Schizophrenia Bulletin · 13
2019 · Maria Jalbrzikowski, David Freedman, et al. · Journal of the American Academy of Child & Adolescent Psychiatry · 31
2018 · Loes M. Olde Loohuis, Monique Albersen, et al. · Genes · 17
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