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Regulation of DNA damage signaling by autophagy in senescence

Description: Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Amount: £303,600
Funding type: research
Start date: 2014-01-08
End date: 2017-04-15
Subfield: Physiology
Field: Medicine
Funded outputs count: 58
Funder award ID: BB/K017314/1
OpenAlex ID: G2561746869
Telomere dysfunction in ageing and age-related diseases
2022 · Francesca Rossiello, Diana Jurk, et al. · Nature Cell Biology · 754
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Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence
2021 · Irene Fernández-Duran, Andrea Quintanilla, et al. · Cell Death and Differentiation · 33
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Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner
2021 · Anthony Lagnado, Jack Leslie, et al. · The EMBO Journal · 211
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Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice
2021 · Mikolaj Ogrodnik, Shane A. Evans, et al. · Aging Cell · 402
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Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis
2021 · Arianna Bianchi, Letizia Marchetti, et al. · The Journal of Immunology · 45
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On the evolution of cellular senescence
2020 · Axel Kowald, João F. Passos, et al. · Aging Cell · 179
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Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span
2020 · Paul D. Robbins, Diana Jurk, et al. · The Annual Review of Pharmacology and Toxicology · 342
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Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery
2020 · Emily Dookun, Anna Walaszczyk, et al. · Aging Cell · 173
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Therapeutic Potential of Senolytics in Cardiovascular Disease
2020 · Emily Dookun, João F. Passos, et al. · Cardiovascular Drugs and Therapy · 69
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Anti‐inflammatory treatment rescues memory deficits during aging in nfkb1−/− mice
2020 · Edward Fielder, Clare Tweedy, et al. · Aging Cell · 71
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Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
2020 · Jasper Iske, Midas Seyda, et al. · Nature Communications · 210
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Telomeres: beacons of autocrine and paracrine DNA damage during skin aging
2020 · Stella Victorelli, João F. Passos · Cell Cycle · 31
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Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy-Related Bone Loss
2020 · Abhishek Chandra, Anthony B Lagnado, et al. · Journal of Bone and Mineral Research · 138
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Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence
2020 · Maria Grazia Vizioli, Tianhui Liu, et al. · Genes & Development · 358
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Corrigendum to ‘Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease’ EBioMedicine 47 (2019) 446–456
2020 · LaTonya J. Hickson, Larissa G.P. Langhi Prata, et al. · EBioMedicine · 59
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Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk
2020 · Liam D. Cassidy, Andrew R. J. Young, et al. · Nature Communications · 108
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Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction
2019 · Stella Victorelli, Anthony Lagnado, et al. · The EMBO Journal · 258
Cellular Senescence: Defining a Path Forward
2019 · Vassilis Gorgoulis, Peter D. Adams, et al. · Cell · 3,223
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Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
2019 · LaTonya J. Hickson, Larissa G.P. Langhi Prata, et al. · EBioMedicine · 1,381
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Expansion and Cell-Cycle Arrest: Common Denominators of Cellular Senescence
2019 · Mikolaj Ogrodnik, Hanna Salmonowicz, et al. · Trends in Biochemical Sciences · 104
Mitochondrial dysfunction and cell senescence: deciphering a complex relationship
2019 · James Chapman, Edward Fielder, et al. · FEBS Letters · 325
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Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition
2019 · Branca I. Pereira, Oliver P. Devine, et al. · Nature Communications · 557
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The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype
2019 · Priya Hari, Fraser R. Millar, et al. · Science Advances · 154
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Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis
2019 · Mikolaj Ogrodnik, Yi Zhu, et al. · Cell Metabolism · 125
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Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction
2019 · Anna Walaszczyk, Emily Dookun, et al. · Aging Cell · 250
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