Trauma Exposure and Cognitive Impairment: Understanding Polygenic Liability and the Causative and Moderating Effects of Exposure, PTSD, and Psychiatric Comorbidity in WTC Responders
Description: Public Relevance to Health: Incidence of cognitive impairment is higher in WTC (World Trade Center) responders than in the general population, and is accompanied by psychiatric comorbidity, including symptoms of PTSD and major depressive disorder (MDD). This proposal has a high-potential to inform health strategies that manage cognitive impairment and psychiatric comorbidity in WTC responders by illuminating the potentially causative and mechanistic roles of exposure severity, PTSD, and depressive symptoms in the emergence and progression of cognitive impairment, while also exploring the more general question of whether trauma exposure and its psychiatric sequalae are causally related to, or exacerbate underlying genetic liability for mental health problems, which is of interest to clinicians, epidemiologists, and psychiatrists alike.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R21
Start date: 2021-08-15
End date: 2024-07-31
Investigator: FRANK D MANN
Institution: STATE UNIVERSITY NEW YORK STONY BROOK
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Funded outputs count: 11
Funder award ID: R21AG074705
OpenAlex ID: G7491658518