Analysis of target gene transitions of a transcription factors involved in retinal Muller cell differentiation and analysis of regenerative activation of retina
Description: Neurons in the human retina do not regenerate once they die, but in some animals, such as fish, Muller cells in the retina can proliferate, transforming into neurons and regenerating the retina. However, mammalian Muller cells, which do not proliferate in vivo, can also proliferate when cultured outside the body. In this study, we focused on this phenomenon. As a result, we were able to capture the genetic changes observed at the onset of proliferation and obtained basic information for application to retinal regeneration in vivo.
Amount: ¥4,680,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2017-04-01
End date: 2022-03-31
Investigator: Norihiro Sudou
Institution: Toho University(2021)Tokyo Women's Medical University(2017-2020)
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 6
Funder award ID: 17K11491
OpenAlex ID: G2587364728