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Pharmacology and Nutritional Sciences: Multidisciplinary Approaches for Metabolic Disease

Description: PUBLIC HEALTH RELEVANCE: Disorders in metabolism are a common feature of most chronic diseases, especially those on the rise in prevalence in the US. We propose to train future scientists to identify ways to use pharmacological (drugs) and nutritional approaches to prevent and treat metabolic disease based-disorders, including obesity/diabetes, cancer, cardiovascular disease and neurodegenerative disease.
Funding type: training
Funder scheme: T32
Start date: 2000-08-15
End date: 2021-07-31
Investigator: NANCY R WEBB
Institution: UNIVERSITY OF KENTUCKY
Funded outputs count: 125
Funder award ID: T32DK007778
OpenAlex ID: G3921591931
A unique inflammaging profile generated by T cells from people with obesity is metformin resistant
2024 · S. SantaCruz-Calvo, S. Saraswat, et al. · GeroScience · 2
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Fasting and Glucose Metabolism Differentially Impact Peripheral Inflammation in Human Type 2 Diabetes
2024 · Gabriella H. Kalantar, Shubh Saraswat, et al. · Nutrients · 4
Elongation of very long chain fatty acids-3 ( Elovl3 ) is activated by ZHX2 and is a regulator of cell cycle progression
2023 · Kate Townsend Creasy, Hui Ren, et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 4
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PCB126 exposure during pregnancy alters maternal and fetal gene expression
2023 · Cetewayo S. Rashid, Joshua D. Preston, et al. · Reproductive Toxicology · 6
Elongation of Very Long Chain Fatty Acids-like 3 (Elovl3) is activated by ZHX2 and is a regulator of cell cycle progression. American Journal of Physiology- Gastrointestinal and Liver Physiology
2023 · Creasy, Kate Townsend, Ren, Hui, et al. · Figshare
Inulin supplementation prior to mild traumatic brain injury mitigates gut dysbiosis, and brain vascular and white matter deficits in mice
2022 · Lucille M. Yanckello, Ya-Hsuan Chang, et al. · Frontiers in Microbiomes · 16
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T cells dominate peripheral inflammation in a cross‐sectional analysis of obesity‐associated diabetes
2022 · Gabriella H. Pugh, Sajjad Fouladvand, et al. · Obesity · 16
Inulin Supplementation Mitigates Gut Dysbiosis and Brain Impairment Induced by Mild Traumatic Brain Injury during Chronic Phase
2022 · Lucille M. Yanckello, Brian Fanelli, et al. · Journal of Cellular Immunology · 19
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Human Gray and White Matter Metabolomics to Differentiate APOE and Stage Dependent Changes in Alzheimer’s Disease
2021 · Tyler C. Hammond, Xin Xing, et al. · Journal of Cellular Immunology · 20
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Neurotensin Regulates Proliferation and Stem Cell Function in the Small Intestine in a Nutrient-Dependent Manner
2021 · Stephanie A. Rock, Kai Jiang, et al. · Cellular and Molecular Gastroenterology and Hepatology · 26
Effects of maternal controlled exercise on offspring adiposity and glucose tolerance
2021 · Kristen M. Platt, Jenna Przybylowski, et al. · Journal of Developmental Origins of Health and Disease · 4
Renal Angiotensinogen Is Predominantly Liver Derived in Nonhuman Primates
2021 · Masayoshi Kukida, Lei Cai, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 25
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Apolipoprotein E genotype-dependent nutrigenetic effects to prebiotic inulin for modulating systemic metabolism and neuroprotection in mice via gut-brain axis
2021 · Lucille M. Yanckello, Jared D. Hoffman, et al. · Nutritional Neuroscience · 27
Immunomodulatory Effects of Azithromycin Revisited: Potential Applications to COVID-19
2021 · Vincent J. Venditto, Dalia Haydar, et al. · Frontiers in Immunology · 84
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MANF is neuroprotective against ethanol-induced neurodegeneration through ameliorating ER stress
2020 · Yongchao Wang, Wen Wen, et al. · Neurobiology of Disease · 43
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Molecular elevation of insulin receptor signaling improves memory recall in aged Fischer 344 rats
2020 · Hilaree N. Frazier, Katie L. Anderson, et al. · Aging Cell · 8
Elevating Insulin Signaling Using a Constitutively Active Insulin Receptor Increases Glucose Metabolism and Expression of GLUT3 in Hippocampal Neurons
2020 · Hilaree N. Frazier, Adam O. Ghoweri, et al. · Frontiers in Neuroscience · 21
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β-amyloid and tau drive early Alzheimer’s disease decline while glucose hypometabolism drives late decline
2020 · Tyler C. Hammond, Xin Xing, et al. · Communications Biology · 111
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APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease
2020 · Ai-Ling Lin, Ishita Parikh, et al. · Neurobiology of Disease · 45
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Prebiotic inulin consumption reduces dioxin-like PCB 126-mediated hepatotoxicity and gut dysbiosis in hyperlipidemic Ldlr deficient mice
2020 · Jessie B. Hoffman, Michael C. Petriello, et al. · Environmental Pollution · 27
Stigmasterol stimulates transintestinal cholesterol excretion independent of liver X receptor activation in the small intestine
2019 · Hannah C. Lifsey, Rupinder Kaur, et al. · The Journal of Nutritional Biochemistry · 47
ABCG5/G8: a structural view to pathophysiology of the hepatobiliary cholesterol secretion
2019 · Aiman A. Zein, Rupinder Kaur, et al. · Biochemical Society Transactions · 72
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Dietary inulin decreases circulating ceramides by suppressing neutral sphingomyelinase expression and activity in mice
2019 · Pan Deng, Jessie B. Hoffman, et al. · Journal of Lipid Research · 34
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Simultaneous Determination of Biliary and Intestinal Cholesterol Secretion Reveals That CETP (Cholesteryl Ester Transfer Protein) Alters Elimination Route in Mice
2019 · Jianing Li, Sonja S. Pijut, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 16
Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model
2019 · Jared D. Hoffman, Lucille M. Yanckello, et al. · PLoS ONE · 127
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