Study of Molecular Mechanisms of Heart Failure
Description: The prognosis of severe heart failure is unacceptably poor and it is urgent to establish new therapies for this critical condition. Some patients with heart failure do not respond to established multidisciplinary treatment and are classified as “non-responders”. The outcome is especially poor for non-responders, and underlying mechanisms are largely unknown. We examined endomyocardial biopsies and metabolomic analysis in patients with idiopathic dilated cardiomyopathy (IDCM). Patients were classified as non-responders when the left-ventricular (LV) ejection fraction and LV end-diastolic dimension did not show more than 10% improvement over the long-term after cardiac biopsy. We here demonstrate that reduction of mitofusin-1 expression impairs cardiomyocyte metabolism and may have a crucial role in the pathology of non-responsive IDCM.
Amount: ¥4,680,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2016-04-01
End date: 2019-03-31
Investigator: Tanaka Komei
Institution: Niigata University
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 14
Funder award ID: 16K09421
OpenAlex ID: G25923538