IGF-1 Regulation of Astrocyte Mitochondrial Metabolism and Redox Homeostasis in Brain Aging
Description: PROJECT NARRATIVE Cognitive decline is a debilitating aspect of aging and age-related neurodegenerative diseases that is closely associated with the decline of a key trophic factor, insulin like growth factor (IGF-1). We have found that IGF-1 signaling deficiency in astrocytes decreases energy charge, increases mitochondrial reactive oxygen species (ROS) and impairs hippocampal-dependent learning. By exploring mechanisms underlying astrocytic dysfunction with age, we will elucidate new avenues for therapy for cognitive decline with age and in disease.
Funder: National Institute on Aging
Funding type: career_development
Funder scheme: K99
Start date: 2018-09-30
End date: 2020-08-31
Investigator: SREEMATHI LOGAN
Institution: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
Funded outputs count: 8
Funder award ID: K99AG056662
OpenAlex ID: G2348723409