Deciphering the ubiquitin code in stress signaling and membrane trafficking
Description: Project Narrative Ubiquitin is a post-translational modification that regulates diverse cellular processes and its dysregulation is associated with many human diseases ranging from neurodegeneration to cancer. Here, we propose research directions that will result in a deeper understanding of how ubiquitin networks are regulated during conditions of stress to facilitate the cellular adaptive response. Dissecting these mechanisms will provide a platform for long-term exploration of ubiquitin networks as potential therapeutic targets in the treatment of human diseases.
Funding type: research
Funder scheme: R35
Start date: 2022-02-01
End date: 2026-12-31
Investigator: JASON A MACGURN
Institution: VANDERBILT UNIVERSITY
Funded outputs count: 11
Funder award ID: R35GM144112
OpenAlex ID: G9000885228