Investigations to Assess the Role of Glucagon Signaling in Healthspan and Aging
Description: Project Narrative More than 25% of the U.S. population greater than 65 years old has Type II diabetes mellitus, representing the highest prevalence of diabetes of any age-group. Most research aimed at understanding the consequences of obesity in aging have focused on insulin and downstream signaling cascades. However, this research has overlooked a potential role for glucagon. Given that many prominent diabetes treatments target glucagon or glucagon signaling pathways, it is essential to understand the role of glucagon in aging. The work proposed in this grant would close a significant gap in our understanding of how glucagon alters aging, while allowing us to assess the potential risks associated with inhibition of glucagon signaling.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R00
Start date: 2017-08-15
End date: 2023-05-31
Investigator: JENNIFER HELENE STERN
Institution: UNIVERSITY OF ARIZONA
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Funded outputs count: 8
Funder award ID: R00AG055649
OpenAlex ID: G8582457355