Impact of T cells on age-related vascular dysfunction: A translational approach
Description: PROJECT NARRATIVE Cardiovascular disease (CVD) is the leading cause of death in the United States and aging is a primary risk factor for CVD primarily due to dysfunction of the arteries. Arterial inflammation appears to play a role in this dysfunction but the precise link is not clear. The results of the proposed studies will indicate whether T cells from the immune system directly mediate age-related vascular dysfunction and have potential to identify specific targets that may be used for early detection and/or drug treatment to reduce CVD burden in the elderly.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2019-04-15
End date: 2025-01-31
Investigator: ANTHONY JOHN DONATO
Institution: UNIVERSITY OF UTAH
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Funded outputs count: 44
Funder award ID: R01AG060395
OpenAlex ID: G3516906010