T cells in the aging brain
Description: NARRATIVE As the organism ages, adult regenerative neural stem cell niches no longer produce new neurons. Adult neurogenic niches have been found to be important for aspects of learning and memory, raising the intriguing possibility that boosting the production of neurons by these niches may help preserve or enhance cognitive function with advancing age. Uncovering the immune-based mechanisms underlying the decline and rejuvenation of adult neurogenic niches during aging should give important insights into the factors that control regeneration in the normal aging nervous system as well as in age-related neurodegenerative diseases such as Alzheimer’s disease.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2021-06-15
End date: 2027-03-31
Investigator: ANNE BRUNET
Institution: STANFORD UNIVERSITY
Funded outputs count: 10
Funder award ID: R01AG071711
OpenAlex ID: G9000915874