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Understanding methionine metabolism and its therapeutic potential in cancer

Description: Diet can affect cancer cell metabolism and nutritional requirements to as large a degree as the oncogenes and tumor suppressor genes. Our preliminary data show that a specific dietary methionine restriction has anti-tumor properties alone or in adjuvant therapy in several cancer models. In this proposal I will dissect the nature of methionine restriction mediated anti-cancer effects for its therapeutic application.
Funding type: research
Funder scheme: R00
Start date: 2022-04-01
End date: 2025-09-30
Investigator: XIA GAO
Institution: BAYLOR COLLEGE OF MEDICINE
Subfield: Biotechnology
Funded outputs count: 13
Funder award ID: R00CA237618
OpenAlex ID: G7573953637
Lineage tracing reveals a shared cellular origin for supraclavicular brown and inguinal beige adipocytes
2026 · Yali Ran, Kai Zhang, et al. · Cell Reports · 1
Genetics-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism
2025 · Dishu Zhou, Ying Chen, et al. · Cell Metabolism · 7
Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress
2025 · Jianpeng Yu, Chen Jin, et al. · Clinical Cancer Research · 7
N-acetylaspartate from fat cells regulates postprandial body temperature
2025 · Jessica B. Felix, Pradip K. Saha, et al. · Nature Metabolism · 6
Hyaluronidase-1 mediates postprandial suppression of hepatic gluconeogenesis
2025 · Xi Chen, Sophie Dogné, et al. · Life Metabolism · 1
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Dual inhibitor of MDM2 and NFAT1 for experimental therapy of breast cancer: in vitro and in vivo anticancer activities and newly discovered effects on cancer metabolic pathways
2025 · Wei Wang, Marlene Aguilar, et al. · Frontiers in Pharmacology · 2
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Dietary Folate and Cofactors Accelerate Age-dependent p16 Epimutation to Promote Intestinal Tumorigenesis
2024 · Li Yang, Robert C. Peery, et al. · Cancer Research Communications · 5
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Heat shock factor 1 directly regulates transsulfuration pathway to promote prostate cancer proliferation and survival
2024 · J. Spencer Hauck, David Moon, et al. · Communications Biology · 9
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Targeting glutamine dependence with DRP‐104 inhibits proliferation and tumor growth of castration‐resistant prostate cancer
2023 · David Moon, J. Spencer Hauck, et al. · The Prostate · 15
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Branched‐Chain Amino Acid Accumulation Fuels the Senescence‐Associated Secretory Phenotype
2023 · Yaosi Liang, Christopher Pan, et al. · Advanced Science · 32
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Increased CaMKK2 Expression Is an Adaptive Response That Maintains the Fitness of Tumor-Infiltrating Natural Killer Cells
2022 · Patrick K. Juras, Luigi Racioppi, et al. · Cancer Immunology Research · 16
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Targeting glutamine metabolism network for the treatment of therapy-resistant prostate cancer
2022 · Lingfan Xu, Bing Zhao, et al. · Oncogene · 31
A Glutaminase Isoform Switch Drives Therapeutic Resistance and Disease Progression of Prostate Cancer
2020 · Lingfan Xu, Yu Yin, et al. · Proceedings of the National Academy of Sciences · 77
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