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MicroRNA-mediated regulation in mammalian skin

Description: PUBLIC HEALTH RELEVANCE: The microRNA pathway is required for mammalian skin development with particularly important functions in hair morphogenesis. In this proposal, I will investigate individual microRNA functions in the control of cell proliferation, adhesion and migration in the hair placode with genetically engineered mouse models. Knowledge gained from the proposed study will provide mechanistic understanding of post-transcriptional regulation in hair development.
Funding type: research
Funder scheme: R01
Start date: 2010-07-01
End date: 2022-03-31
Investigator: RUI YI
Institution: NORTHWESTERN UNIVERSITY AT CHICAGO
Subfield: Urology
Field: Medicine
Funded outputs count: 24
Funder award ID: R01AR059697
OpenAlex ID: G354544170
Escape of hair follicle stem cells causes stem cell exhaustion during aging
2021 · Chi Zhang, Dongmei Wang, et al. · Nature Aging · 84
Transgenic overexpression of the miR-200b/200a/429 cluster inhibits mammary tumor initiation
2021 · Katrina L Watson, Rui Yi, et al. · Translational Oncology · 5
Inhibition of microRNA turns back the CLOCK of hair follicle aging
2021 · Chi Zhang, Rui Yi · Nature Aging · 3
XPO5 promotes primary miRNA processing independently of RanGTP
2020 · Jingjing Wang, Jerome E. Lee, et al. · Nature Communications · 40
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Integrated analysis of directly captured microRNA targets reveals the impact of microRNAs on mammalian transcriptome
2020 · Glen A. Bjerke, Rui Yi · RNA · 22
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The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation
2019 · Siddharth Shukla, Glen A. Bjerke, et al. · Molecular Cell · 94
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Is it time to take R(epressive) out of PRC1?
2019 · Dongmei Wang, Rui Yi · Genes & Development · 3
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Single Cell and Open Chromatin Analysis Reveals Molecular Origin of Epidermal Cells of the Skin
2018 · Xiying Fan, Dongmei Wang, et al. · Developmental Cell · 72
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The microRNA-200 family coordinately regulates cell adhesion and proliferation in hair morphogenesis
2018 · Jaimee E. Hoefert, Glen A. Bjerke, et al. · The Journal of Cell Biology · 68
The Skin(ny) on Regenerating the Largest Organ to Save a Patient’s Life
2018 · Rui Yi · Cell stem cell · 3
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Concise Review: Mechanisms of Quiescent Hair Follicle Stem Cell Regulation
2017 · Rui Yi · Stem Cells · 69
Genome-wide analysis of Musashi-2 targets reveals novel functions in governing epithelial cell migration
2016 · Christopher G. Bennett, Kent Riemondy, et al. · Nucleic Acids Research · 55
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MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells
2015 · Kent Riemondy, Xiao-jing Wang, et al. · eLife · 18
Highly Efficient Ligation of Small RNA Molecules for MicroRNA Quantitation by High-Throughput Sequencing
2014 · Jerome E. Lee, Rui Yi · Journal of Visualized Experiments · 6
Not miR ‐ly micromanagers: the functions and regulatory networks of microRNAs in mammalian skin
2014 · Kent Riemondy, Jaimee E Hoefert, et al. · Wiley Interdisciplinary Reviews - RNA · 7
Stem cell quiescence acts as a tumour suppressor in squamous tumours
2013 · A. C. White, J. K. Khuu, et al. · Nature Cell Biology · 71
High-efficiency RNA cloning enables accurate quantification of miRNA expression by deep sequencing
2013 · Zhaojie Zhang, Jerome E Lee, et al. · Genome biology · 63
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3′UTRs take a long shot in the brain
2013 · Li Wang, Rui Yi · BioEssays · 32
MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway
2013 · Dongmei Wang, Zhaojie Zhang, et al. · Nature Cell Biology · 137
Rapid and widespread suppression of self-renewal by microRNA-203 during epidermal differentiation
2013 · Sarah J. Jackson, Zhaojie Zhang, et al. · Development · 77
Genome-wide maps of polyadenylation reveal dynamic mRNA 3′-end formation in mammalian cell lineages
2013 · Li Wang, Robin D. Dowell, et al. · RNA · 41
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Quantitative functions of Argonaute proteins in mammalian development
2012 · Dongmei Wang, Zhaojie Zhang, et al. · Genes & Development · 179
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A miR Image of Stem Cells and Their Lineages
2012 · Rui Yi, Elaine Fuchs · Current topics in developmental biology/Current Topics in Developmental Biology · 17
MicroRNAs and their roles in mammalian stem cells
2011 · Rui Yi, Elaine Fuchs · Journal of Cell Science · 98
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