Functional analysis of (pro)renin receptor in the genesis of pancreatic cancer
Description: The aim of this study is to elucidate whether (pro)renin receptor [(P)RR] is involved in the genesis of pancreatic ductal adenocarcinoma (PDAC). Human whole-genome analysis revealed that aberrant (P)RR expression induced massive chromosomal rearrangements and enhanced the total number of somatic mutations at the global level in human pancreatic ductal epithelial (HPDE) cells, which are capable of transforming into PDAC. (P)RR-expressing HPDE cell population engrafted into the renal subcapsules of immunodeficient mice showed the biological characters of malignant tumour such as atypical cells including abnormal nuclear shapes. (P)RR overexpression also resulted in the failure of genomic stability pathways such as DNA replication, DNA repair and telomere maintenance. In conclusion, our findings demonstrate that aberrant (P)RR expression induces genomic instability by the disorder of genomic stability pathways.
Amount: ¥3,770,000
Funding type: research
Funder scheme: Grant-in-Aid for Challenging Exploratory Research
Start date: 2016-04-01
End date: 2018-03-31
Investigator: Yuki Shibayama
Institution: Kagawa University
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Funded outputs count: 6
Funder award ID: 16K14610
OpenAlex ID: G2644834610