Metabolic dynamics of vitamin K by elucidation of vitamin K side chain cleavage enzyme
Description: Vitamin K plays an important role in blood clotting and bone formation. While PK is the main vitamin K ingested by humans through the diet, the majority of vitamin K present in tissues is MK-4. We have scientifically demonstrated that PK is converted to MK-4 by UBIAD1 in tissues after its side chain is cleaved in the small intestine to the intermediate MD. However, the mechanism of side chain cleavage to MD is still unclear, and the whole picture of "vitamin K metabolism dynamics" is still unclear. In this study, we aimed to understand the metabolic mechanism of vitamin K. We conducted a comprehensive analysis and searched for effective side-chain cleavage enzymes using new vitamin K derivatives. The results of this study are expected to clarify the significance of the metabolic conversion of vitamin K.
Amount: ¥4,290,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Yoshihisa Hirota
Institution: Shibaura Institute of Technology
Funded outputs count: 14
Funder award ID: 18K11056
OpenAlex ID: G267830132